多囊卵巢综合征患者的糖耐量和胰岛素测定

Determination of Glucose Tolerance and Insulin in Patients with Polycystic Ovary Syndrome

目的探讨多囊卵巢综合征患者(PCOS)糖代谢和胰岛素分泌的特征。方法49例PCOS患者和21例对照组按体重指数(BMI)分为3组:对照组、PCOSⅠ组(BMI<25kg/m2)、PCOSⅡ组(BMI≥25kg/m2),比较3组的糖耐量及胰岛素水平。结果与对照组比较,PCOSⅠ组空腹及口服葡萄糖后各组血糖差异均无统计学意义(P>0.05);胰岛素除空腹差异无统计学意义外(P>0.05),其余各组胰岛素释放量均有统计学意义(P<0.05)。PCOSⅡ组口服葡萄糖后1h、2h血糖明显升高(P<0.05);胰岛素各组释放量差异均有统计学意义(P<0.05)。与PCOSⅠ组比较,PCOSⅡ组口服葡萄糖后1h、2h胰岛素释放量也有统计学意义(P<0.05)。结论PCOS患者胰岛素释放量明显增加,肥胖可加重患者的胰岛素释放,导致PCOS患者高胰岛素血症进一步发展,且更易出现糖代谢异常,增加糖尿病发生的危险性。

Objective To investigate the characteristics of glucose metabolism and insulin secretion in patients with polycystic ovary syndrome（PCOS）. Methods According to body mass index（BMI） ,49 cases of PCOS patients were divided into PCOS Ⅰ group （ BMI 〈 25 kg/m^2 ） and PCOS Ⅱ group （ BMI ≥ 25 kg/m^2 ） ;21 healthy people were set as control. The glucose tolerance and insulin levels of three groups were analyzed. Results Compared with control group, PCOS Ⅰ fasting and oral glucose in each group there was no significant difference in blood glucose （ P 〉 0.05 ）. In addition to fasting plasma insulin was no significant difference between the outer（ P 〉 0.05 ）, other groups of insulin release were statistical significance （ P 〈 0.05 ）. PCOS Ⅱ group after oral glucose 1 h or 2 h, glucose was significantly higher（ P 〈 0.05 ） ;insulin release in each group differences were statistically significant（P 〈 0.05）. Compared with PCOS Ⅰ group, after oral glucose 1 h or 2 h , insulin release of PCOS Ⅱ group was also statistically significant （P 〈 0.05 ）. Conclusion Significant increase in insulin release in patients with PCOS, obesity can increase insulin release,leading to PCOS patients the further development of hyperinsulinemia, and more prone to abnormal glucose metabolism, increasing the risk of diabetes.