不同病期精神分裂症患者血浆皮质醇水平的观察

An observation on the levels of serium cortisol among different ill-courses in patients with schizophrenia

目的:观察不同病期精神分裂症患者的血浆皮质醇水平,探讨患者的阴阳性症状与血浆皮质醇水平的关系。方法:以精神分裂症患者70例为研究组,于治疗前0周、治疗后2周末和4周末应用阴阳性症状量表(PANSS)分别评定患者发病期和好转期的阴阳性症状,并同步测定血浆皮质醇水平,观察其阴阳性症状与血浆皮质醇水平变化的关系,同时与30例健康者作对照。结果:研究组的PANSS总分在发病期(0周和2周末)和好转期(第4周末)均显著高于正常对照组(P<0.05或P<0.01)。研究组的血浆皮质醇水平在发病期显著升高(P<0.01),随着病情的好转而恢复正常。研究组血浆皮质醇水平的变化(0周与2周末,2周末与4周末)与同期PANSS总分、阳性症状、敌对攻击等因子分的变化值呈正相关(r=0.1814,0.1789,0.1843),但无显著性(P>0.05)。结论:精神分裂症患者发病期伴有血浆皮质醇水平升高,在不同病期有不同程度的阴阳性症状,但各精神症状与血浆皮质醇水平无明确关联。

Objective： To observate the levels of serium cortisol among different ill - courses in patients with schizophrenia and to explore the correlation between the changes of the positive or negative symptoms and the levels of serium cortisol during different ill - courses, nethods： Totally 60 patients with schizophrenia （the study group） were evaluated with Scale （PANSS） before treatment,after 2 weeks and after 4 weeks of treatment,and at the same time, the levels of serium cortisol were tested, with 30 healthy controls. Results： During onset period（0 week,2nd weekend of treatment） and the recovery period （4th weekend of treatment）, the scores of PANSS in the study group were significantly higher than those of the control group （ P 〈 0.05 or P 〈 0.01 ）. The level of serium cortisol in the study group significantly increased during onset period （ P 〈 0.01 ） and recovered with ill - condition improvement. There showed positive correlation between the levels of sedum cortisol and the changes of the total scores of PANSS and the factors of positive symptom, hostility and attack symptom in the study group （0 week to 2nd weekend, 2nd weekend to 4th weekend）（r = 0. 1814, 0. 1789,0. 1843）, but no significant difference （P 〉 0.05）.Conclusion： During different illcourses, patients with schizophrenia had some extent positive or negative symptoms and had higher level of serium cortisol during onset period. But there showed no clear correlation between the levels of serium cortisol and the psychotic symptoms.