妊娠合并病毒性肝炎39例临床分析

Analysis of pregnancy with virus hepatitis in 39 cases

目的:探讨妊娠与肝炎的关系。方法:回顾性分析39例妊娠期肝炎患者的临床资料,并与同期育龄非妊娠病毒性肝炎患者比较。结果:妊娠期肝炎以乙型肝炎为主,其次为甲型、丙型、戊型肝炎病毒感染,部分肝炎病原不明;妊娠合并肝炎以中晚期妊娠为主;随妊娠周数增加,肝炎发病率及重型肝炎发生率、病死率增加;妊娠期肝炎凝血酶原时间(PT)明显延长,白蛋白(ALB)显著降低,并发肝性脑病和肝肾综合征均高于非妊娠肝炎组(P<0.05)。结论:妊娠期肝炎临床特点与非妊娠病毒性肝炎有所不同,对妊娠期肝炎应高度重视,及早采取应对措施。

Objective：To explore the relationship between pregnancy and hepatitis.Methods：The clinical data of 39 pregnant patients with virus hepatitis were retrospectively analyzed and compared wit h non-pregnanct reproductive women of hepatitis in the comtemporaneous period.The pathogeny, indexes of hepatic function and clinical pathogenetic characteristic were compared.Results ： Virus hepatitis in pregnancy was mostly type B hepatitis,and the next was hepatitis A,hepatitis C and hepatitis E, few hepatitis was agnogenie. Pregnancy associated with hepatitis happened at mid and last stage gestation mostly;the morbility of hepatitis increased gradually along with the progress of pregnant weeks, so did the incidence and fatality of severe hepatitis ; the prothrombin time （PT） significantly prolonged in pregnancy with virus hepatitis, and albumin decreased significantly,the complications of hepatocerebral disease and hepatorenal syndrome were more than non-pregnancy with virus hepatitis（P〈0.05）.Conclusion ：The clinical pathogenetic characteristic of pregnancy with virus hepatitis is different from non-pregnancy with virus hepatitis.More attention should be paid to pregnancY with virus hepatitis,the measures should be taken early.