N,N’-二羧甲基大环醚双内酯的合成改进及机理

Synthetic Improvements and Mechanism of N,N'-dicarboxymethyl Macrocyclic Ether-bislactones

本文报道在无水、氮气保护下EDTA二酐与多缩乙二醇反应生成N，N’－二羧甲基大环醚双内酯（1—4）的合成改进及其机理。

This paper reports the synthetic improvements and mechanism of a series of N,N'-dicarboxymethyl macrocyclic ether-bislactones. The reaction was obtained in very dilute anhydrous solution and protected by nitrogen through whole process.