注射用头孢呋辛钠溶液颜色检查不合格测定结果分析

Analysis of Cefuroxime Sodium for Injection with Solution Colour Disqualification

目的针对4批颜色不合格注射用头孢呋辛钠进行结果分析。方法目测法和紫外-可见分光光度法检查注射用头孢呋辛钠溶液颜色,并采用2种溶剂对样品作不同处理。结果3次目测法结果与1次紫外-可见分光光度法测定结果基本一致,2种溶剂对检查结果没有明显影响。结论紫外-可见分光光度法可与目测法相结合,作为注射用头孢呋辛钠颜色的检查手段之一。

Objective To analyze the results of 4 batch of cefuroxime sodium for injections with solution colour disqualification. Methods The solution colour was determined by visual observation and ultraviolet - visible absorption spectroscopy, and the samples Were separately dissolved in 2 solvents. Results Three results of visual observation were accordant with the result by ultraviolet - visible absorption spectroscopy. Two difference solvents had no significant effect on the results. Conclusion The combination method of visual observation and ultraviolet - visible absorption spectroscopy can be used for the determination of colour of cefuroxime sodium for injections.