中枢协调障碍高危因素分析

Logistic Regression Analysis to Possible Risk Factors for Central Coordination Disturbance

目的探讨小儿中枢性协调障碍(CCD)发病的相关危险因素。方法以2007年1月—2008年10月我院儿科脑瘫病区收治的134例中枢性协调障碍患儿为调查对象,采用1:2匹配设计选择同期收治的非CCD患儿和健康儿童为对照,选取26个调查项目进行调查,对结果分别进行单因素Logistic回归分析和多因素Logistic回归分析。结果多因素条件Logistic回归分析显示有统计学意义的因素有早产、缺氧缺血性脑病、新生儿神经行为测定(NBNA)和头颅CT结果四项。结论本研究提示早产、缺氧缺血性脑病、NBNA<37分、头颅CT异常四项为CCD患儿的高危因素。

Objective To identify possible risk factors for central coordination disturbance（CCD） in children. Methods A Population-based survey was conducted（ including 134 CCD cases） in the hospital from Jan, 2007 to Oct, 2008. A totol of 268 matched controls（ ratio 1：2 ） who were non-CCD patients or health children and hospital during the same time were selected for comparison. Twenty-six investigated items were chosen, and the results were analyzed with single-factors Logistic regression and multi-factors Logistic regression respectively. Results Multi-factors Logistic regression analysis identified which were statistically significant for risk of CCD included premature delivery, asphyxia of newborn, NBNA count method of premature birth and skull CT scanning. Conclusion The research indicates that premature delivery, asphyxia of newborn, NBNA count method of premature birth and abnormal skull CT scanning findings are the four risk factors for CCD.