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瞬时受体电位通道与心律失常的关系 被引量：2

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摘要 瞬时受体电位通道(TRP)超家族组成超过50种阳离子通道,分布在几乎所有心血管组织中,可以整合多种物理和化学的刺激诱导Ca2+进入胞内。TRP通道家族对心脏节律的维持起着关键作用:TRPC可能通过钙池操纵Ca2+通道参与起搏调控;肥厚心肌中TRPM4表达上调,通过瞬时性内向电流(Iti)参与延迟后除极的发生;TR-PC1和TRPC6参与牵张诱发性心律失常的发生;在缺血缺氧的病理条件下,ATP/UTP的释放激活TRPC3/7引发心电异常。将来有望通过干预TRP活性来开发新一代的抗心律失常药物。
作者 孙智慧 郑良荣
机构地区 浙江大学医学院附属第一医院心血管内科
出处 《中国心脏起搏与心电生理杂志》 北大核心 2010年第1期74-76,共3页 Chinese Journal of Cardiac Pacing and Electrophysiology
基金 浙江省科技攻关计划(项目编号:2006C33010)
关键词 心血管病学 瞬时受体电位通道 综述 心律失常
分类号 R541.7 [医药卫生—心血管疾病]
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参考文献27

  • 1Watanabe H, Murakami M, Ohba T, et al. TRP channel and cardiovascular disease [ J]. Pharmacol Ther, 2008, 118 : 337.
  • 2Cosens DJ, Manning A. Abnormal electroretinogram from a Drosophila mutant [J]. Nature, 1969, 224:285.
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同被引文献9

  • 1Inoue R, Jensen L J, Shi J, et al. Transient receptor potential channels in cardiovascular function and disease [J]. Circ Res, 2006,99: 119-131.
  • 2Ai X, Pogwizd SM. Connexin 43 downregulation and dephosphorylation in non-ischemic heart failure is associated with enhanced colocalized protein phosphatase type 2A[J]. Heart Circ Res, 2005,96(1): 54-63.
  • 3Maroto R, Raso A, Wood TG, et al. TRPC1 forms the stretch-activated cation channel in vertebrate cells [J]. Nat Cell Biol,2005, 7(2): 179-185.
  • 4Kamkin A, Kiseleva I, Wagner KD, et al. Characterization of stretch-activated ion currents in isolated atrial myocytes from human hearts[J]. Pflugers Arch,2003, 446(3) : 339-346.
  • 5Seol CA, Kim WT, Ha JM, et al. Stretch-activated currents in cardiomyocytes isolated from rabbit pulmo nary veins[J]. Prog Biophys Mol Biol, 2008, 97(2-3) : 217-231.
  • 6Bode F, Sachs F, Franz MR. Tarantula peptide inhib its atrial fibrillation during stretch[J]. Nature, 2001, 409: 35-36.
  • 7Suchyna TM, Johnson JH, Hamer K, et al. Identifica tion of a peptide toxin from grammostola spatulata spider venom that blocks cation-selective stretch activated channels[J]. J Gen Physiol, 2000,115:583-598.
  • 8Franz MR, Bode F. Mechano-electrical feedback underlying arrhythmias:the atrial fibrillation case [J]. Prog Biophys Mol Biol,2003,82(1-3) : 163-174.
  • 9任璐,黄思慧,吴林.瞬时受体电位M4通道相关的心脏疾病[J].中国心脏起搏与心电生理杂志,2015,29(2):173-175. 被引量：3

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中国心脏起搏与心电生理杂志
2010年 第1期

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