胺碘酮联合酒石酸美托洛尔治疗慢性心衰合并室性心律失常的疗效观察

Study on Effect of Amiodarone Combined with Metoprolol Tartrate in Treating Chronic Congestive Heart Failure with Ventricular Arrhythmia

目的探讨胺碘酮联合酒石酸美托洛尔治疗慢性心衰合并室性心律失常的临床效果。方法将2007年1月～2009年1月间在我院住院治疗的慢性心衰合并室性心律失常104例,随机分为治疗组和对照组,两组采用抗心衰药物治疗,治疗组同时给予盐酸胺碘酮治疗。结果治疗后各组心率、射血分数、QT离散度均有明显改善,治疗前后比较差异具有统计学意义(P<0.05)。治疗后治疗组在心率、射血分数和QT离散度方面明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗组总有效率为96.15%,对照组为76.92%,两组比较差异具有统计学意义(P<0.05)。治疗期间两组均无严重窦性心动过缓、心功能恶化、室性心律失常加重或猝死病例。结论胺碘酮联合酒石酸美托洛尔治疗慢性心衰合并室性心律失常的临床效果好,未见毒副作用,值得临床应用。

Objective To investigate the effect ofamiodarone combined with metoprolol tartrate in treating chronic congestive heart failure with ventricular arrhythmia. Methods 104 cases with chronic congestive heart failure and ventricular arrhythmia in our hospital from January 2007 to January 2009 were divided into the treatment group and the control group respectively. The two groups received the anti-congestive heart failure drug, and the treatment group also received the amiodarone combined with metoprolol tartrate. Results The heart rate, ejection fraction and straggling of QT after treatment were superior to those before treatment, and there was significant difference （P〈0. 05）. The heart rate, ejection fraction and straggling of QT after treatment in the treatment group were superior to those in control group, and there was significant difference in them （P〈0.05）. The total effective rate was 96.15% in the treatment group and 76.92% in the control group and there was significant difference in them （P〈0.05）. There was no severe sinus bradycardia, heart function deterioration, ventricular arrhythrnias aggravation and sudden death eases. Conclusion The effect of amiodarone combined with metoprolol tartrate in treating chronic congestive heart failure with ventricular arrhythmia is obvious and there is no side effect, which deserves clinical application.