二甲双胍改善多囊卵巢综合征患者的内皮功能及胰岛素抵抗被引量：11

METFORMIN IMPROVES ENDOTHELIAL FUNCTION AND INSULIN RESISTANCE IN PCOS PATIENTS

下载PDF

导出

摘要目的探讨二甲双胍对多囊卵巢综合征的患者的胰岛素抵抗及内皮功能的作用。方法40例多囊卵巢综合征患者分为肥胖组和非肥胖组,检测二甲双胍治疗前后患者的血脂谱、胰岛素抵抗指数(HO-MA-IR)、胰岛素敏感指数(ISI)及内皮依赖性舒张(EDV)功能的变化。结果肥胖组的血脂谱和HOMA-IR明显高于非肥胖组,肥胖组的ISI和EDV明显低于非肥胖组。经过16周二甲双胍的治疗后,肥胖组和非肥胖组的血脂谱和HOMA-IR明显下降,ISI和EDV明显上升。结论二甲双胍可以改善多囊卵巢综合征的患者的胰岛素抵抗及内皮功能。 Objective To observe the influence of metformin on endothelial function and insulin resistance in PCOS patients. Methods Plasma hpid spectra level, HOMA - IR, ISI and endothelium - dependent vasodilation （EDV） were measured before and after metformin therapy in 40 PCOS patients （20 normal weight and 20 obese）. Results Plasma lipid spectra level and HOMA - IR were higher in obese PCOS than in normal weight PCOS, ISI and EDV were lower in obese PCOS than in normal weight PCOS. Plasma lipid spectra level and HOMA - IR were decreased significantly; ISI and EDV were increased significantly in PCOS after mefformin therapy. Conclusion Metformin improves vascular endothelial function and insulin resistance in PCOS patients.

作者顾建芬陈立波张长宁吕术昕

机构地区深圳市第六人民医院(南山医院)

出处《现代医院》 2010年第2期18-19,共2页 Modern Hospitals

关键词多囊卵巢综合征胰岛素抵抗内皮功能二甲双胍 PCOS, Insulin resistance, Endothelial function, Mefformin

分类号 R711.7 [医药卫生—妇产科学] R587.1 [医药卫生—内分泌]

引文网络
相关文献

参考文献10

1SORENSEN M B, FRANKS S, ROBERTSON C, PENNELL D J, COLLINS P. Severe endothelial dysfunction in young women with polycystic ovary syndrome is only partially explained by known cardiovascular risk factors. Clin Endocrinol (Oxf) 2006; 65 : 655 - 659.
2The Rotterdam ESHRE/ASRM Sponsored PCOS Consensus Workshop Group. Rivised 2003 consensus on diagnostic criteria and long term health risked related to polycystic ovary syndrome[ J]. Fertil Steril,2004,81 : 19 - 25.
3CELERMAJER D S, SORENSEN K E, GOOCH V W, et al. Non invasive detection of endothelial dysfunction in children and adult s at risk of atherosclerosis [ J ]. Lancet, 1992,340 : 1111 - 11151.
4CARMINA E,BUCCHIERI S,ESPOSITO A,et al. Abdominal fat quantity and distribution in women with polycystic ovary syndrome and extent of its relation to insulin resistance[ J]. J Clin Endocrinol Metab,2007,92(7) :2500 -2505.
5CARMINA E, ORIO F, PALOMBA S,et al. Endothelial dysfunction in PCOS : role of obesity and adipose hormones [ J ]. Am J Med ,2006,119 : 16.
6戴晓君.达英-35联合二甲双胍治疗多囊卵巢综合征的疗效[J].实用医学杂志,2009,25(10):1663-1665. 被引量：18
7朱筱丹.二甲双胍联合吡格列酮治疗多囊卵巢综合征的疗效观察[J].实用医学杂志,2009,25(13):2141-2142. 被引量：18
8全启花,余琳,陈敦金,杨洁.二甲双胍联合综合促排卵治疗多囊卵巢综合征的临床研究[J].国际医药卫生导报,2009,15(10):5-7. 被引量：3
9梁凤霞.达英-35联合二甲双胍对肥胖型POOS内分泌治疗的临床疗效观察[J].国际医药卫生导报,2008,14(11):39-42. 被引量：5
10ROMUALDI D, COSTANTINI B, SELVAGGI L, et al. Mefformin improves endothelial function in normoinsulinemic PCOS patients: a new prospective [ J]. Hum Reprod ,2008,23 ( 9 ) :2127 - 33.

二级参考文献27

1梅志雄,覃炜.二甲双胍联合复方醋酸环丙孕酮治疗多囊卵巢综合征40例临床分析[J].南方医科大学学报,2006,26(5):657-658. 被引量：8
2任琛琛.达英-35联合二甲双胍治疗多囊卵巢综合征疗效观察[J].中国误诊学杂志,2006,6(11):2073-2074. 被引量：5
3刘锦霞,党洁明,吴元赭,郑宁,吴效科.二甲双胍联合环丙孕酮/炔雌醇治疗多囊卵巢综合征的临床研究[J].医学研究生学报,2006,19(6):530-533. 被引量：30
4Solomon CG.The epidemiology of polycysfic ovary synd, 11e. Prevalenceand associated disease risks[J].Endocrinol Metab Clin North Am, 1999, 28: 247-263.
5Cataldo NA, Barnhart HX, Legro RS, et al, Extendedrelease metformin does not reduce the clomiphene citrate dose required to induce ovulation in polycystic ovary syndrome[J].J Clin Endocrinol Metab. 2008 , 93(8):3124- 3127.
6Jakimiuk AJ. Metformin therapy in polycystic ovary syndrome [J].GinekolPol, 2008, 79(1):8-11.
7Motta DA. Metformin in the treatment of polycystic ovary syndrome[J].Curr Pharm Des. 2008;14(21):2121-2125. Review.
8Heutling D, Schulz H, Nickel I, et al, Asymmetrical dimethylarginine, inflammatory and metabolic parameters in women with polycystic ovary syndrome before and after metformin treatment[J].J Clin Endocrinol Metab. 2008,93 (1):82-90.
9Tankova T. Current indications for metformin therapy[J]. Rom J Intern Med, 2003;41(3):215-225. Review.
10Carmina E.Dignosis of polycystic ovary syndrome:from NIH criteria to ESHRE-ASRM guidelines[J].Minerva Ginecol,2004,56(1):126.