重复经颅磁刺激治疗帕金森病的参数与疗效
摘要
帕金森病(Parkinson’s disease,PD)是由于黑质多巴胺能神经元数目减少导致的运动障碍病,该病临床表现及病理生理机制多样,且症状个体差异大。有研究揭示PD的病理生理机制与递质紊乱、基底节一皮质环路异常等有关。多巴胺替代疗法是药物有效治疗PD的基石,能很好改善运动症状,但存在多巴胺抵抗症状,如冻僵步态、认知缺陷、抑郁、痴呆等。另外,长期使用多巴胺能药物治疗可能导致运动波动及异动症。
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2010年第2期142-145,共4页
Chinese Journal of Neurology
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