哌拉西林诱导铜绿假单胞菌L型形成的实验研究

Induction of Pseudomonas aeruginosa L-forms with piperacillin

目的:观察哌拉西林诱导铜绿假单胞菌变异为L型的情况。方法:采用平板纸片法和液体浓度梯度法,利用哌拉西林药物纸片诱导铜绿假单胞菌标准菌株变异为L型,并稳定传代。结果:铜绿假单胞菌可被哌拉西林诱导为典型L型,在诱导因素存在下可稳定传代。结论:哌拉西林可诱导铜绿假单胞菌变异为稳定L型。

Objective： To observe the induction of Pseudomonas aeruginosa （P. aeruginosa） L-forms with piperacillin. Methods：In plate and liquid media within antibiotic piperacillin,P, aeruginosa was induced into L-forms which would go down to posterity stably. Results：P. aeruginosa was induced to typical and stable L-forms by piperacillin. Conclusions：P. aeruginosa L-form is an important existing form of P. aeruginosa.