2型糖尿病合并肾动脉粥样硬化性狭窄68例临床分析

Clinical analysis of 68 subjects with type 2 diabetes mellitus combined with atherosclerotic renal artery stenosis

目的:探讨2型糖尿病患者合并肾动脉粥样硬化性狭窄的预测因素。方法:选择经血管造影或磁共振血管成像证实存在肾动脉粥样硬化性狭窄(ARAS)的2型糖尿病患者68例和无ARAS的2型糖尿病患者44例,对两组患者的年龄、性别、糖尿病病程、高血压病程、血脂、糖化血红蛋白、血肌酐(Cr)、血尿酸(UA)、合并其他大血管病变情况进行统计学分析。结果:两组临床资料中年龄、高密度脂蛋白、Cr、UA和其他大血管病变的差异均有统计学意义(P<0.01),其余各指标间差异均无统计学意义(P>0.05);肾动脉梗阻与患者年龄、Cr、UA、其他大血管病变数均呈正相关关系(P<0.05～P<0.01),与高密度脂蛋白呈负相关关系(P<0.05)。结论:2型糖尿病患者年龄、高密度脂蛋白、Cr、UA水平及有无其他大血管病变是ARAS的预测因素。

Objective： To assess the predictor factors for atherosclerotic renal artery stenosis（ARAS） in type 2 diabetes mellitus. nethods：A total of 68 subjects with type 2 diabetes mellitus combined with ARAS confirmed by intra-arterial angiography or magnetic resonance angipgraphy,and 44 subjects with no ARAS were included in the study. The patients＇ age, sex, duration of diabetes and hypertention, blood lipid, glycosylated hemoglobin, creatinine, uric acid, and other atherosclerotic diseases were analyzed statistically. Results：There were significant differences in age, creatinine, uric acid and other atherosclerotic diseases between the two groups. ARAS was positively associated with age, creatinine, uric acid and other atherosclerotic diseases （ P 〈 0.05 - P 〈 0. 01 ）, and negatively associated with high density lipoprotein-C （ P 〈 0.05 ）. Conclusions ： Age, high density lipoprotein-C, blood creatinine, uric acid and other atherosclerotic diseases are predictor factors for ARAS.