腹腔镜引导下125I粒子植入治疗复发妇科恶性肿瘤的安全性评估

The safety evaluation of laparoscopic-guided 125I seed implantation in the treatment of recurrent gynecologic malignancies

目的探讨腹腔镜下手术切除及125I粒子植入治疗复发妇科恶性肿瘤的安全性。方法5例复发妇科恶性肿瘤患者在腹腔镜下切除复发癌灶并植入125I粒子，记录全部并发症，用γ射线监测仪在距放射源不同距离及术后不同时间监测环境辐射剂量。结果5例手术全部成功，无严重的并发症发生，所有患者均有轻微的粒子植入部位疼痛和暂时外阴水肿，离放射源距离及术后时间增加，辐射剂量迅速减少，在距离体表50cm及术后6个月时测得的辐射剂量接近天然本底辐射剂量。结论腹腔镜下手术切除及125I粒子植入对患者及周围人群是安全的。

Objevtive To investigate the safety of laparoscopie resection and 125I seed implantation for recurrent gynecologic malignancies. Methods Laparoscopic surgery and 125I seed implantation were used in five patients. All complications were recorded. Environmental radiation dose was detected at different distance from radioactive source and different time after operation withγ-ray equipment. Results The procedure was safely achieved in all five patients. No serious complication was found. All patients experienced slight pain at the implant site and temporary vulva dropsy. With the increase of the distance from radioactive source and time passing, the radiation dose decreased quickly. The detected dose was close to a natural background radiation dose at the distance of 50cm from radioactive source and after 6 months. Conclusions Laparoscopic resection and 125I seed implantation are safe to patient and environment.