CYP4F2基因G20597A多态性与高血压病相关性研究

Association between the G20597A variant of CYP4F2 gene and essential hypertension

目的分析我国汉族人群CYP4F2基因多态性与原发性高血压的关系。方法选择189例高血压病患者和187例年龄相匹配的健康人群为研究对象，采用PCR．RFLP方法对CYP4F2G20597A多态性位点进行基因型分析。结果CYP4F2G20597A基因型、等位基因在高血压病组和对照组差异无统计学意义，但是在以性别为基础进行分层分析时，携带CYP4F220597G等位基因男性在患高血压组与无高血压组差异有统计学意义（81．6％vs71．3％，P〈0．05），在多元Logistic回归分析予以校正心血管病多种危险因子后（吸烟，TC，基因型，年龄及BMI），男性CYP4F220597GG携带者患高血压病风险约为CYP4F220597GA和AA基因型携带者的2．689倍。结论CYP4F2基因G20597A多态性与我国男性高血压病具有相关性，并且CYP4F220597GG基因型可能为我国汉族男性高血压病的一个独立危险因子。

Objective To analyze relationship between the gene polymorphism of CYP4F2 and essential hypertension （EH） in China＇s Han population. Methods 189 EH patients and 187 age-matched controls were used to analysis G20597A polymorphism site of CYP4F2 gene with polymerase chain-restriction fragment length polymorphisms. Results There was no difference of neither genotype nor allele of CYP4F2 （G20597A） between EH and controls through stratified analysis on gender. CYP4F2 gene 20597G allele cartiers had significant association with EH for male in China （81.6% vs 71.3%, P =0. 019）, but not with female. After adjustment for cardiovascular risk factors （including smoking, TC, age, genetype, BMI） , the hazard ratio for incident EH in male with CYP4F2 20597GG increased about 2. 689 than that with CYP4F2 20597GA and 20597AA. Conclusion CYP4F2 20597G allele has significant association with male EH, and CYP4F2 20597GG may be an independent predictor of EH for male in china＇s Han population.