肝癌患者凝血功能变化及临床意义

Changes in coagulation function in patients with hepatocellular carcinoma and its clinical significance

目的探讨肝癌时凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)的变化及临床意义。方法66例肝癌患者和58例健康者进行了血浆凝血四项的检测且观察凝血功能与Ch ild-Pugh肝功能分级的关系,观察30例手术患者行相同方式手术时术中出血量与术后3d血浆管引流量的变化。结果肝癌导致凝血机制的变化随着肝功能分级降低PT、APTT、TT逐渐延长,FIB逐渐降低,三级中的PT、APTT、TT、FIB差异均有统计学意义。手术患者随着肝功能分级的降低,术中出血量与术后3d血浆管引流量也在增加。结论凝血四项指标的检测能及时、准确地反映肝癌患者肝脏的损害程度和凝血功能情况。

Objective To evaluate the liver cancer when the prothrombin time （PT）, activated partial thromboplastin time （APTT）, thrombin time （TT）, fibrinogen （FIB） and the clinical significance of the changes. Methods 66 cases of liver cancer patients and 58 healthy persons were detected in plasma coagulation and the observation of four coagulation function and liver function Child-Pugh classification of the relationship between the observed 30 cases of surgical patients with the same manner as the volume of blood loss during surgery and plasma after a three-day changes in drainage pipes. Results The liver lead to changes in blood coagulation mechanism of liver function with lower grade PT, APTT, TT gradually extended, FIB decreased in three of the PT, APTT, TT, FIB significant differences were liver function of patients with lower grade, after three days of bleeding volume and the plasma tube drainage are also increasing. Conclusion Detection of four indicators of coagulation can promptly and accurately reflect the liver damage in patients with liver function and coagulation.