亚甲基四氢叶酸还原酶基因多态性与中国人群食管癌易感性的Meta分析

Methylenetetrahydrofolate Reductase Polymorphisms and Susceptibility to Esophageal Cancer in Chinese Population:Meta-analysis

目的运用Meta分析的方法综合评价中国人群中亚甲基四氢叶酸还原酶(MTHFR)基因多态性与食管癌发病的相关性。方法通过计算机文献检索中国生物医学文献数据库(CBM)和PubMed数据库,并结合文献追溯、网上查询(www.baidu.com;www.google.cn)的方法,收集所有关于MTH-FR基因多态性与食管癌易感性的病例对照研究或队列研究。以食管癌组与对照组人群基因型分布的OR值为效应指标,各资料间进行一致性检验,以确定采用固定或随机效应模型进行合并分析。发表偏倚用漏斗图和Egger’s线性回归检验来评估。结果共有在国内外发表的相关文献10篇纳入分析,Meta分析结果表明:MTHFRC677T基因多态和MTHFRA1298C基因多态合并OR值及其95%CI分别为1.97(1.69,2.30),0.84(0.66,1.08)。按是否吸烟进行分层发现吸烟组中MTHFR677CT/TT基因型与食管癌有关(OR=2.57,95%CI:1.73～3.80),而不吸烟组中未见MTHFR677CT/TT基因型与食管癌存在关联(OR=1.33,95%CI:0.94～1.88)。结论中国人群MTHFRC677T基因多态性与食管癌易感性有关,MTHFRA1298C基因多态性与食管癌易感性无统计学关联。吸烟可能会增加MTHFRC677T基因型个体患食管癌的危险性。

Objective To study the relationship between Methylenetetrahydrofolate reductase polymorphisms and susceptibility to esophageal cancer in Chinese populations by Meta-analysis. Methods Computer literature searching was carried out in CBM and PubMed database to collect the articles of the case-control studies on association between MTHFR polymorphism and susceptibility to esophageal cancer,also performed searching based on www.baidu.com and www.google.cn.Odds ratio was employed to evaluate the susceptibility to esophageal cancer and MTHFR status.Heterogeneity was checked by chi-square test.Publication bias was assessed by using a funnel plot and Egger’s test.Results Ten papers were selected.Meta-analysis found that OR （95%CI） for polymorphisms of the MTHFRC677T and MTHFRA1298C were 1.97 （1.69,2.30） and 0.84 （0.66,1.08） respectively.Stratification analysis showed that OR for the MTHFRC677T and esophageal cancer among the smoke group was 2.57 （95%CI：1.73-3.80）; OR for the MTHFRC677T and esophageal cancer among the non-smoke group was 1.33 （95%CI：0.94-1.88）. Conclusion Polymorphisms of MTHFRC677T had statistically significant association between the MTHFR variants and susceptibility to esophageal cancer,MTHFRA1298C and esophageal cancer failed to show statistically significant association.The MTHFRC677T genotype with smoking might be associated with the increased risk of esophageal cancer.