摘要
目的:建立银黄分散片体外溶出度的检测方法,为质量控制提供方法和参数。方法:经溶出(溶出介质及转速)方法考察,最终确定以水为溶出介质,转速为75 r/min,用HPLC法测定,以外标法计算黄芩苷和绿原酸的溶出百分量。结果:银黄分散片中的黄芩苷及绿原酸的溶出度符合《中国药典》要求。结论:所用方法灵敏、准确、快速,能有效监控本品质量。
Objective: To establish inspecting method of vitro dissolution of Yinhuang disket, that supplied method and parameter for quality control. Methods: By dissolution method investigation, the water were made dissolution media, with 75 r/rain rotary speed, HPLC method determined and calculated dissolution percent component of baicalin and caffeotannic acid. Re- suits: The dissolution of baicalin and caffeotannic acid in Yinhuang disket consisted with the request of 〈China pharmacopeia 〉. Conclusion: The method is sensitive, accurate, quikcly, can control the quality of this preparation.
出处
《中医药导报》
2010年第2期67-69,共3页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
关键词
银黄分散片
黄芩苷
绿原酸
溶出度
Yinhuang Disket
Baicalin
Caffeotannic acid
Dissolution