摘要
目的:建立银黄分散片体外溶出度的检测方法,为质量控制提供方法和参数。方法:经溶出(溶出介质及转速)方法考察,最终确定以水为溶出介质,转速为75 r/min,用HPLC法测定,以外标法计算黄芩苷和绿原酸的溶出百分量。结果:银黄分散片中的黄芩苷及绿原酸的溶出度符合《中国药典》要求。结论:所用方法灵敏、准确、快速,能有效监控本品质量。
Objective： To establish inspecting method of vitro dissolution of Yinhuang disket, that supplied method and parameter for quality control. Methods： By dissolution method investigation, the water were made dissolution media, with 75 r/rain rotary speed, HPLC method determined and calculated dissolution percent component of baicalin and caffeotannic acid. Re- suits： The dissolution of baicalin and caffeotannic acid in Yinhuang disket consisted with the request of 〈China pharmacopeia 〉. Conclusion： The method is sensitive, accurate, quikcly, can control the quality of this preparation.
出处
《中医药导报》
2010年第2期67-69,共3页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
关键词
银黄分散片
黄芩苷
绿原酸
溶出度
Yinhuang Disket
Baicalin
Caffeotannic acid
Dissolution
