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miRNAs在涎腺肿瘤中的研究进展 被引量：2

Research Advances of miRNAs in Tumors of Salivary Glands
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摘要 miRNAs是一种广泛存在、高度保守的调控基因表达的小分子非编码RNA，通过miRNAs介导的特异性基因沉默导致靶miRNAs降解及抑制蛋白质的合成，调控转录后基因表达水平．在细胞生长、发育、代谢等重要生命过程中扮演重要角色，成为近年来生命科学研究的新领域。在肿瘤等疾病，伴随着疾病的发生与发展，经常伴有miRNAs的异常，包括表达水平的变化或序列突变等，而恢复miRNAs的正常表达，往往会显著阻止甚至逆转病情的发展。
作者 汤亚玲 梁新华 陈宇
机构地区 四川大学口腔疾病研究国家重点实验室
出处 《口腔颌面外科杂志》 CAS 2010年第1期64-67,共4页 Journal of Oral and Maxillofacial Surgery
基金 国家自然科学基金资助(30872889) 教育部留学回国人员启动基金资助(20098-8-2)
关键词 MIRNAS 涎腺肿瘤 肿瘤转移 miRNAs salivary gland tumor tumor metastasis
分类号 R739.87 [医药卫生—肿瘤]
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参考文献21

  • 1武雪梅,肖华胜.miRNA与肿瘤细胞耐药的关系[J].中国科学（C辑）,2009,39(9):813-820. 被引量：5
  • 2Caldas C, Brenton JD. Sizing up miRNAs as cancer genes [J]. Nat Med, 2005, 11(7):712-714.
  • 3Zhang L, Huang J,Yang N, et al. microRNAs exhibit high frequency genomic alterations in human cancer [J]. Proc Nad Acad Sci USA, 2006, 103(24):9136-9141.
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  • 8Calin GA, Sevignani C, Dumitru CD, et al.Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers [J]. Proc Natl Acad Sci USA, 2004, 101(26):2993-3004.
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二级参考文献38

  • 1Lippert T H, Ruoff H J, Volm M. Intrinsic and acquired drug resistance in malignant tumors. The main reason for therapeutic failure. Arzneimittelforschung, 2008, 58:261- 264.
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  • 8Caldas C, Brenton J D. Sizing up miRNAs as cancer genes. Nat Med, 2005, 11:712-714.
  • 9Zhang L, HuangJ, Yang N, et al, microRNAs exhibit high frequency genomic alterations in human cancer. Proc Natl Acad Sci USA,2006,103:9136 -9141.
  • 10Calin G A, Sevignani C, Dumitru C D, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA, 2004, 101:2999- 3004.

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口腔颌面外科杂志
2010年 第1期

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