西酞普兰合并低剂量阿米替林与帕罗西汀治疗抑郁症的疗效观察

Effieaey of Citalopram Combined with Low-dose Amitriptyline and Parexetine in the Treatment of Depression

目的探讨西酞普兰合并低剂量阿米替林与帕罗西汀治疗抑郁症的疗效价值和安全性。方法对2009年1月-2009年10月我院门诊及住院抑郁症患者112例，随机分为西酞普兰合并低剂量阿米替林组和帕罗西汀组各56例，疗程6周，采用汉密顿抑郁量表（HAMD）和不良反应量表（TESS）在治疗前、后1、2、4、6周末评定药物疗效和不良反应。结果西酞普兰合并低剂量阿米替林和帕罗西汀两组治疗1～2周前后HAMD评分差异有显著性（P〈0．05），治疗4—6周，两组差异无显著性（P〉0．05），西酞普兰合并低剂量阿米替林组不良反应总发生率为26．79％，帕罗西汀则为46．43％，两组差异有显著性（P〈0．05）。结论西酞普兰合并低剂量阿米替林与帕罗西汀治疗抑郁症均有效，不良反应较轻，但西酞普兰合并低剂量阿米替林更安全，服用方便，不良反应更小，可作为治疗抑郁症的首选联合药物。

Objective To study value and safety of the citalopram combined with low-dose amitriptyline and paroxetine in the treatment of depression. Methods Collecting from January 2009 to October 2009 in our hospital out-patient and hospitalization in patients with depression, 112 cases were randomly divided into combined low dose of citalopram paroxetine amitriplyline group and 56 cases of two groups, treatment for 6 weeks using Hamilton Depression Rating Scale （ HAMD ） and adverse reactions Scale （ TESS ） in the treatment of pre-and post assessment of 1, 2, 4, 6 weekend efficacy and adverse reactions of drugs. Reasults Citalopram combined with low-dose amitriptyline and paroxetine in the treat- ment groups 1 - 2 weeks before and after the HAMD score difference was significant（ P〈0.05 ）, treatment for 4 - 6 weeks, no significant difference between the two groups （ P〉0.05 ）, citalopram combined group of low-dose amitriptyline in the overall incidence of adverse reactions 26.79%, paroxetine, compared with 46. 43%, difference between two groups was statistically significant （ P〈 0.05 ）. Conclusion Citalopram combined with low-dose amitriptyline and paroxetine in the treatment of depression are effective and less adverse reactions, but combined with low-dose of citalopram amitriptyline more secure, taking convenient, less adverse reactions, can be used as treatment of depression drug of choice.