妇科腔镜手术后氟比洛芬酯静脉镇痛的临床观察

Effect of flurbiprofen axetil for postoperative patient-controlled intravenous analgesia in patients underwent laparoscopic surgery in treating women diseases

目的观察妇科腔镜手术后患者氟比洛芬酯自控静脉镇痛（PCIA）的效果与不良反应。方法选择ASAⅠ～Ⅱ级妇科腔镜手术后行PCIA患者60例，随机均分为两组。芬太尼组术后PCIA予芬太尼500ug＋昂丹司琼8mg；氟芬组术后PCIA予氟比洛芬酯100mg＋芬太尼250Pg＋昂丹司琼8mg，手术结束前10min静脉予氟比洛芬酯50mg为负荷剂量。两组PCIA均以昂丹司琼作为止吐药，均用生理盐水稀释至100ml。两组PCIA泵的设置相同：维持量2ml／h，单次负荷剂量0．5ml，锁定时间15min。观察两组术后48h的镇痛评分（VAS）、镇静评分（SS）及不良反应发生率。结果两组术后镇痛及镇静评分差异无显著性（P〉0．05），氟芬组药物不良反应发生率低于芬太尼组。结论氟比洛芬酯用于妇科腔镜手术后PCIA，镇痛效果与单纯芬太尼相似，但不良反应明显减少，提高了镇痛质量。

Objective To evaluate the effect and side effect of postoperative patient-controlled intravenous analgesia with flurbiprofen axetil in patients underwent laparoscopic surgery in treating women diseases. Methods 60 cases of such patients that should be ASA class Ⅰ or Ⅱ were randomly divided into two groups equally with 30 cases each. Fentanyl Group was given fentanyl 500 ug plus ondansetron 8 mg diluted to 100 ml via PCIA after surgery, flurbiprofen Group was administrated fentanyl 250 ug, and flurbiprofen axetil 100 mg plus ondansetron 8mg diluted 100ml via PCIA after surgery, the loading dose was flurbiprofen axeti150 mg ten minutes prior to the end of the operates. The PCIA rate was 2 ml/h, blous 0.5 ml, lock time 15 min. Analgesia and sedation grade were accessed and side effects were recorded. Resulta There was no significant difference in analgesia and sedation grade between two groups. The side effects were lower in flurbiprofen Group than those in fentanyl Group. Conclusion Co-administration of flurbiprofen axetil by PCIA offers overall favorable analgesic responses as well as the reduction of fentanyl consumption during PCIA in the patients following laparoscopic surgery.