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线粒体融合蛋白2与心血管疾病 被引量：8

Mitochondrial Fusion Protein Mfn2 and Cardiovascular Diseases
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摘要 线粒体融合蛋白2(mitofusin2,Mfn2)不仅是一种不可或缺的调控线粒体形态和功能的动力素(dynamin)相关蛋白,还是一个重要的细胞内信号分子,参与调控细胞增殖、分化、凋亡等生命过程。Mfn2与高血压、冠状动脉腔内成形术后再狭窄、动脉粥样硬化、心肌肥厚、心肌氧化损伤等多种心血管疾病的病理生理过程密切相关,并通过调节物质代谢影响糖尿病和胰岛素抵抗等的发病。此外,Mfn2还可能是心血管疾病的一个重要的分子标志和治疗靶分子。 Mitofusin 2 （Mfn2）is a mitochondrial dynamin-related protein involved in the mitochondrial fusion reaction and is also connected to an altered mitochondrial energy supply. Mfn2 is a signaling molecule, plays an important role in cell proliferation, differentiation and apoptosis, which participates in the pathophysiology of several cardiovascular diseases, such as hypertension, restenosis after angioplasty, ath- erosclerosis, cardiac hypertrophy, and cardiac oxidative stress injury. Regulating the mitochondria-related metabolism, Mfn2 affects diabetes and insulin resistance pathogenesis. In addition, Mfn2 could be an im- portant biomarker and therapeutic target molecule for cardiovascular diseases.
作者 于海奕 郭艳红 高炜
机构地区 北京大学第三医院心内科
出处 《生理科学进展》 CAS CSCD 北大核心 2010年第1期11-16,共6页 Progress in Physiological Sciences
基金 国家高技术研究发展计划(863计划 2008AA02Z441) 高等学校博士学科点专向科研基金(20060001143)资助课题
关键词 线粒体融合蛋白2 心血管疾病 增殖 凋亡 信号转导 mitofusin 2 cardiovascular diseases proliferation apoptosis cell signaling
分类号 R331 [医药卫生—人体生理学]
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参考文献20

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共引文献65

同被引文献85

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生理科学进展
2010年 第1期

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