期刊文献+

神经元衔接蛋白X11L通过调节APP代谢抑制Aβ生成 被引量:2

下载PDF
导出
摘要 X11L是一种神经元特异的衔接蛋白,可通过调节APP代谢抑制Aβ生成。X11L抑制Aβ生成的机制包括:X11L与APP结合,减少APP易位入富含β-和γ-分泌酶的DRM区域,抑制APP生成Aβ的途径;X11L与NF-kB/p65结合,阻止NF-kB/p65核转位,抑制NF-κB/p65诱导的Aβ生成。跨膜蛋白Alc可促进X11L对Aβ生成的抑制作用,而XB51蛋白可阻止X11L对Aβ生成的抑制作用。深入探讨X11L在APP代谢中的作用及其机制,将有助于揭示阿尔采末病(AD)尤其是绝大多数散发性AD(SAD)的发病机制,并最终采取有效防治措施。
出处 《生理科学进展》 CAS CSCD 北大核心 2010年第1期47-51,共5页 Progress in Physiological Sciences
基金 国家自然科学基金资助课题(30973160)
  • 引文网络
  • 相关文献

参考文献10

  • 1Tomita S, Ozaki T, Taru H, et al. Interaction of a neuronspecific protein containing PDZ domains with Alzheimer's amyloid precursor protein. J Biol Chem, 1999, 274:2243 - 2254.
  • 2Lee JH, Lau KF, Perkinton MS, et al. The neuronal adaptor protein Xllbeta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice. J Biol Chem, 2004,279 : 49099 -49104.
  • 3Sumioka A, Saito Y, Sakuma M, et al. The X11L/X11beta/ MINT2 and X11L2/X11gamma/MINT3 scaffold proteins shuttle between the nucleus and cytoplasm. Cell Res, 2008, 314 : 1155 -1162.
  • 4Tara H, Suzuki T. Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein. J Biol Chem, 2004, 279 : 21628-21636.
  • 5Sano Y, Syuzo-Takabatake A, Nakaya T, et al. Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the XllL-deficient mouse brain. J Biol Chem, 2006,281 : 37853 - 37860.
  • 6Saito Y, Sano Y, Vassar R,et al. X11 proteins regulate the translocation of APP into detergent resistant membrane and suppress the amyloidogenic cleavage of APP by BACE in brain. J Biol Chem, 2008, 283 : 35763 -35771.
  • 7Gross GG, Feldman RM, Ganguly A, et al. Role of Xll and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila. PLoS ONE, 2008,3 : e2495.
  • 8Tomita S, Fujita T, Kirino Y,et al. PDZ domain-dependent suppression of NF-kappaB/p65-induced Abeta42 production by a neuron-specific X11-like protein. J Biol Chem, 2000, 275 : 13056 - 13060.
  • 9Araki Y, Tomita S, Yamaguchi H, et al. Novel cadherinrelated membrane proteins, alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism. J Biol Chem, 2003, 278 : 49448 - 49458.
  • 10Lee DS, Tomita S, Kirino Y, et al. Regulation of X11 L- dependent amyloid precursor protein metabolism by XB51, a novel X11 L-binding protein. J Biol Chem, 2000,275 : 23134 -23138.

同被引文献32

引证文献2

二级引证文献11

相关主题

;
使用帮助 返回顶部