炎症和脉络膜新生血管关系的研究进展

Relation between inflammation and choroidal neovascularization

脉络膜新生血管(choroidal neovascularization,CNV)是一直以来困扰眼科界的难题之一。大量实验证实,炎症与CNV存在密切关系,因炎症而激活的巨噬细胞、中性粒细胞等炎细胞释放的肿瘤坏死因子-α、白细胞介素和细胞间黏附分子等多种炎症介质共同形成了一个复杂的网络体系,极大的推动了CNV的发生发展。

Choroidal neovascularization（CNV） has always been one of the most difficult problems of ophthalmology.Many experiments have confirmed that inflammation and CNV are closely connected.A complicated network system is composed of many inflammatory cells,such as macrophages and neutrophilic granulocytes,and inflammation mediators,such as tumor necrosis factor-α,interleukin and intercellular adhesion molecules,and this network system promotes the pathogenesis of CNV.