原发性高血压血管紧张素原、血管紧张素转化酶、心房钠尿肽基因多态性分析

The Gene Polymorphisms of Angiotensinogen,Angiotensin Converting Enzyme and Atrial Natriuretic Peptide in Essential Hypertension

目的研究中国南方汉族人群中血管紧张素原、血管紧张素转化酶及心房钠尿肽基因多态性与原发性高血压的关系。方法选择原发性高血压患者81例及对照者120例,采用基因芯片技术检测血管紧张素原、血管紧张素转化酶及心房钠尿肽基因多态性,并比较其基因型及等位基因频率。结果高血压组血管紧张素原TT基因型频率为53.1%,与对照组(45.8%)比较,差异无统计学意义(P>0.05);高血压组患者血管紧张素转化酶DD基因型频率为48.1%,与对照组(4.2%)比较,差异具有统计学意义(P<0.001);高血压组心房钠尿肽CC基因型频率为6.1%,与对照组(8.3%)相比,差异亦无统计学意义(P>0.05)。结论血管紧张素转化酶基因多态性可能与原发性高血压的发生有相关性。

Aim To investigate the association between the polymorphisms of angiotensinogen gene（AGT235）,angiotensin converting enzyme gene（ACEI/D）,atrial natriuretic peptide gene（ANP2238） and essential hypertension in a southern Chinese Han population.Methods Performed by gene chip technology,the genotypes of 81 essential hypertensive people and 120 control people were measured to analyze the polymorphisms of AGT235,ACEI/D and ANP2238.Results A significantly higher frequency of ACEI/D DD genotype was observed in hypertensive group（48.1% vs 4.2%,P0.001） than in control group.In hypertensive group,the frequency of AGT235 TT genotype and ANP2238CC genotype was respectively 53.1% and 6.1%,while it was respectively 45.8% and 8.3% in control group.No significant differences were observed（P0.05）.Conclusion The polymorphism of ACEI/D gene is related to essential hypertension.