栀子总苷对小剂量阿司匹林诱发大鼠胃粘膜损伤的保护作用研究

Experimental study on the effect of total glycosides of Zhizi(栀子) on gastric mucosal lesion induced by low dose aspirin in rats

目的:研究栀子总苷(TGZ)对小剂量阿司匹林诱发胃粘膜损伤的保护作用。方法:采用TGZ(140,70,35mg/kg)与小剂量阿司匹林(5.0mg/kg)连续ig给药14d,观察胃粘膜损伤指数和胃粘膜血流量(GMBF),并同时检测血清丙二醛(MDA)的含量和超氧化物歧化酶(SOD)的活性,以及胃粘膜的病理组织学变化。结果:TGZ用药组的胃粘膜损伤指数较模型对照组显著降低,胃粘膜局部血流量升高,同时能减轻胃组织炎细胞浸润,明显改善胃粘膜的病理组织学变化;与模型对照组比较,MDA含量降低,SOD活性明显提高。结论:栀子总苷对小剂量阿司匹林诱发的胃粘膜损伤有明显的保护作用。

Objective：To study the protective effect of total glycosides of Zhizi（TGZ） on gastric mucosal lesion induced by low dose aspirin in rats.Methods：Used TGZ（140,70,35mg∕kg） and low dose aspirin（5.0mg/kg） ig continuous administration 14d,measured the lesion index and gastric mucosal blood flow（GMBF） of rats in TGZ（140,70,35mg∕kg） and control groups.The content of malondialdehyde（MDA） and super oxide dismutase（SOD） activity in blood and histopathological changes of gastric mucosa were determined as well.Results：Gastric mucosal lesion index of all TGZ dosage groups was obviously reduced and GMBF was increased as compared with model group.It could relieve inflammatory cell infiltrate in gastric tissue and ameliorate the histopathological changes of gastric mucosa.Compared with model group,TGZ（140,70,35mg/kg,ig 14d）could lower MDA content and raise SOD activity.Conclusion：TGZ can inhibite gastric mucosal lesion induced by low dose aspirin.