摘要
目的:研究七氟醚对行胃癌根治术患者围术期前炎因子的影响。方法:30例行胃癌根治术患者随机分为对照组和七氟醚组,每组15例。患者一般资料差异无统计学意义。七氟醚组于麻醉后持续吸入1%七氟醚至手术结束;对照组不采用任何吸入性麻醉药。分别于麻醉后即刻(T1)、腹腔探查即刻(T2)、手术结束即刻(T3)、术后2h(T4)、4h(T5)5个时点抽取深静脉血4mL,酶联免疫吸附试验(ELISA)测定血清肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)和白细胞介素8(IL-8)浓度。结果:2组患者T1血浆TNF-α、IL-6、IL-8浓度均在正常范围内,组间比较差异无统计学意义。与T1比较,T2~T5TNF-α、IL-6、IL-8浓度均增高,差异有统计学意义(P<0.05)。与对照组比较,七氟醚组在各个时点(T1~T5)TNF-α、IL-6、IL-8浓度均降低,差异有统计学意义(P<0.05)。结论:在胃癌根治术麻醉中应用七氟醚,可以减轻患者围术期前炎因子水平,对抑制手术过度应激反应有帮助。
Objective: To study the effect of sevoflurane on pro-inflammatory cytokines in gastric cancer surgery. Methods: Thirty patients of gastric cancer were divided into two groups randomly: Control group (n=15)and Sevoflurane group (n=15). There was no statistically significant difference between two groups in general state of health. In Sevoflurane group, from the beginning of the operation to the end, patiens were given continuously 1% sevoflurane inhalation. Plasma levels of tNF-a、 IL-6、IL-8 were measured at the following moments, immediately after induction of anesthesia(T1),immediately after intra-abdominal exploration (T2), immediately after surgery (T3), 2 h and 4 h after surgery(T4 and T5). Results: Plasma levels of TNF-a, IL-6, IL-8 were normaland there was no statistically significant difference between two groups in the moment of T1. Compared with T1, the levels increased significantly at T2~T5 in both groups (P〈0.05).The levels of TNF-a, IL-6, IL-8 in sevoflurane group were significantly lower than those in the control group in the moments of T2, T3, T3, T4, T(5P〈0. 05). Conclusion: Sevoflurane can effectively inhibit the inflammation response in gastric cancer surgery.
出处
《中国现代普通外科进展》
CAS
2009年第12期1049-1051,共3页
Chinese Journal of Current Advances in General Surgery
关键词
七氟醚·前炎因子·胃肿瘤
Sevoflurane·Pro-inflammatory cytokines·Stomach neoplasms