潮汕地区1920例乳腺癌临床病理特点分析

Clinical and pathological features of 1 920 patients with breast cancer in Chaoshan area

目的:分析潮汕地区乳腺癌患者的临床病理学特点。方法:收集1990-01-2006-07汕头大学医学院病理教研室确诊的1920例潮汕地区乳腺癌患者的病理资料,分析其临床病理学特点。结果:1990-2006年每年诊断病例呈逐渐上升趋势。全组中位年龄48岁(19～89岁),最高发病年龄段40～49岁占39.1%(750/1920),其次50～59岁占26.0%(500/1920)。主要病理类型为浸润性导管癌占91.9%(1765/1920);ER、PR均阳性占56.0%(1069/1908),ER、PR均阴性占31.4%(599/1908);c-erbB-2(+++)占45.4%(522/1150)。ER、PR与c-erbB-2成负相关,r分别为-0.229和-0.348,P<0.001;ER与PR成正相关,r=0.738,P<0.001。ER、PR、c-erbB-2表达均与患者年龄无相关,P值分别为0.412、0.273和0.693;ER、PR与c-erbB-2表达均与病理类型无相关,P值分别为0.113、0.393和0.154。结论:潮汕地区乳腺癌年确诊病例呈逐渐上升趋势,40～59岁年龄段常见,浸润性导管癌占91.9%,ER、PR、c-erbB-2表达与患者年龄和病理类型均无相关。

OBJECTIVE：To study and analyze the clinical and pathological features of the patients with breast cancer in Chaoshan area. METHODS：The clinical and pathological features of 1 920 patients with breast cancer pathologically confirmed in Chaoshan area in the department of pathology of Shantou University Medical College from January 1990 to July 2006 were evaluated and analyzed. RESULTS：There was an ascending tendency in the number of annual newly diagnosed cases from 1990 to 2006. The median age of the patients in all the groups was 48 years （ranging from 19 to 89 years）. The highest incidence in age of onset was ranging from 40 to 49 years 〔39.1%（750/1 920）〕,and the second highest incidence in age of onset was ranging from 50 to 59 years 〔26.0%（500/1 920）〕. The major pathological type was invasive ductal carcinoma with 91.9%（1 765/1 920）. The incidence was 56.0%（1 069/1 908）with both ER and PR positive by the immuno-histochemical （IHC） test,and 31.4%（599/1 908） with both ER and PR negative,while the incidence was 45.4% （522/1 150） with c-erbB-2 overexpression （＋＋＋） by the c-erbB-2 IHC test. The expressions of ER and PR were both negatively associated with that of c-erbB-2,and the correlation coefficients （r） were -0.229 and -0.348,respectively （P0.001）. The expression of ER was positively associated with that of PR,and the correlation coefficient （r） was 0.738（P0.001）. The expressions of ER,PR and c-erbB-2 were not correlated with the ages of patients （P=0.412,P=0.273,and P=0.693,respictively）,nor were those correlated with the pathological types （P=0.113,P=0.393,and P=0.154,respictively）. CONCLUSION：There is an ascending tendency in the annual new diagnosis of patients with breast cancer in Chaoshan area,especially in women from 40 to 59 years old,among which invasive ductal carcinoma accountes for 91.9%,while the expressions of ER,PR and c-erbB-2 are correlated with neither ages nor pathological types.