肿瘤干细胞研究进展

Advances in research of cancer stem cells

目的:了解近年来肿瘤干细胞的研究进展。方法:应用检索Pubmed数据库检索系统,以"肿瘤"、"干细胞"、"肿瘤干细胞"为关键词,检索1979-01-2008-12的相关文献,共检索到英文文献2760条。纳入标准:1)肿瘤干细胞的表面标志、耐药机制、信号传导通路;2)肿瘤干细胞来源;3)肿瘤干细胞与肿瘤临床诊治的联系。根据纳入标准,最后精选33篇文献进行分析综述。结果:肿瘤干细胞能够自我更新和分化,具有特异的表面分子标志,对放化疗不敏感。肿瘤干细胞存在Wnt、Notch、Hedgehog、Bmi-1等调节细胞自我更新信号通路异常。肿瘤干细胞是维持肿瘤生长、复发和转移的根源,已经成为抗肿瘤研究的靶细胞。结论:肿瘤干细胞研究进展迅速,深入研究肿瘤干细胞的特性,对恶性肿瘤的诊断,治疗和预后评估具有重要意义。肿瘤干细胞理论将改变目前肿瘤的诊治模式。

OBJECTIVE：To summarize the advances in the researches about cancer stem cells in last 5 years. METHODS：With the keywords ＂neoplasms,stem cell and cancer stem cells＂ ,2 760 papers published from Jan 1979 to Dec 2008 were searched in the Pubmed databases. Adoptive standards：1） the surface markers,drug-resistance mechanism and signal transduction pathways of cancer stem cells. 2） the origin of cancer stem cells. 3） cancer stem cells and clinical oncology. According to the adoptive standards,33 top-quality papers were chosen for reviewing. RESULTS：Cancer stem cells have the properties of self-renewal and differentiation,with special cell surface markers and drug-resistance. The signal transduction pathways of cancer stem cells including Wnt,Notch,Hedgehog and Bmi-1 were abnormal. Cancer stem cells are the origin of malignant tumor＇s growth,recurrence and metastasis,having been the target of anti-cancer research. CONCLUSIONS：Rapid progress has been made in the research about cancer stem cells. The thorough study on cancer stem cells is significant for the diagnosis,treatment and prognosis evaluation of malignant tumor. The theory of cancer stem cells will change the current cancer diagnosis and treatment model.