2型糖尿病正常糖耐量一级亲属抗氧化能力的研究

Antioxidant capacity in patients with type 2 diabetes and their first-degree relatives with normal glucose tolerance

目的观察2型糖尿病患者及其正常糖耐量一级亲属抗氧化能力的改变。方法随机选取58例2型糖尿病患者作为糖尿病组;72例上述患者正常糖耐量一级亲属作为观察组;年龄、性别和体质量指数匹配、无糖尿病家族史的35例健康志愿者作为对照组。比较各组的超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)、谷胱甘肽过氧化物酶(GSH-PX)、总抗氧化能力(T-AOS)的改变。结果与对照组相比,糖尿病组SOD、NO、GSH-PX和T-AOS明显降低(P<0.05),MDA明显升高(P<0.05)。观察组的SOD有降低趋势(P=0.058),MDA有升高趋势(P=0.052),NO、GSH-PX、T-AOS无明显变化。结论2型糖尿病患者抗氧化能力明显降低,其正常糖耐量一级亲属抗氧化能力亦有降低趋势。

Objective To investigate the changes of antioxidant ability in patients with type 2 diabetes mellitus and their normoglycemic first-degree relatives. Methods 58 patients with type 2 diabetes mellitus were selected as the diabetes group, 72 normoglycemic first-degree relatives as the observation group, and 35 healthy controls without a diabetic family history matched for age, sex and body mass index as the control group. Changes of superoxide dismutase （SOD）, maleic dialdehyde（ MDA）, nitric oxide（ NO）, glutathione peroxidase（GSH-PX） and total antioxidant status（T-AOS） were compared. Results SOD, NO, GSH-PX and T-AOS were significantly lower （P 〈 0. 05 ） and MDA was higher （ P 〈 0. 05 ） in the diabetic group compared with those in the control group; SOD showed an increasing trend （ P = 0. 058 ） and MDA showed a decreasing trend （ P = 0. 052 ） in the observation group. But NO, GSH-PX and T-AOS had no significant changes. Conclusions Antioxidant ability significantly declines in patients with type 2 diabetes mellitus, and also shows a declining trend in their normoglycemic first-degree relatives.