广州地区胰腺癌相关抑郁症的临床发病状况调查

Incidence of pancreatic cancer related depression in Guangzhou, China

目的探讨我国广州地区胰腺癌相关抑郁症的临床发病状况。方法采用多中心、前瞻性调查设计，纳入2007年6月至2009年6月广州地区4家医院收治的50例胰腺癌、60例肝癌、50例食管癌、50例胃癌及52例结直肠癌住院患者。采用汉密顿抑郁量表-24（HAMD-24）评估患者的抑郁状况。结果胰腺癌伴发抑郁症的发生率为78．0％（39／50），显著高于肝癌的60．0％（36／60）、胃癌的36．0％（18／50）、食管癌的24．0％（12／50）、结直肠癌的19．2％（10／52）（P值均〈0．05）。其中胰腺癌患者中有24．0％（12／50）为严重抑郁症，明显高于肝癌的10．0％（6／60）、胃癌的4．0％（2／50）、食管癌及结直肠癌患者的0（P值均〈0．05）。胰腺癌晚期患者抑郁症发生率为94．3％，明显高于早期患者的46．7％（P〈0．01）；接受化疗患者的抑郁症发生率为92．3％，显著高于手术患者的62．5％（P〈0．05）。结论与消化系统其他癌症相比，胰腺癌相关抑郁症的临床发生率最高，且抑郁程度较重。

Objective To investigate the incidence of pancreatic cancer-related depression in Guangzhou, China. Methods A multicenter, prospective survey was conducted, 50 patients with pancreatic cancer, 60 with liver cancer, 50 with esophageal cancer, 50 with gastric cancer, 52 with colorectal cancer were enrolled from 4 hospitals in Guangzhou between June 2007 and June 2009. Hamilton Rating Scale for Depression-24 （HAMD-24） questionnaire was used to assess the degree of depression. Results The incidence of depression in pancreatic cancer patients was 78% （39/50） , which was significantly higher than that among liver cancer patients （60%, 36/60 ） , gastric cancer patients （36% , 18/50 ） , esophageal cancer patients （24%, 12/50）, and colorectal cancer patients （ 19.2%, 10/52, P 〈 0.05）. Twelve of 50 patients in pancreatic cancer were reported to have severe depression （ 24% ） , which was significantly more than that in liver cancer （10% , 6/60） , gastric cancer （4% , 2/50）, esophageal and colorectal cancer （0,P 〈 O. 05）. In pancreatic cancer patients, the incidence of depression was significantly higher in patients with advanced stage （94.3%） than that in early stage （46.7%, P 〈 0.05）. Patients who underwent chemotherapy had high incidence of depression （92.3%） than that of patients who underwent operation （62.5% , P 〈 0.05 ）. Conclusions Compared with other cancers of digestive tract, the incidence of pancreatic cancer-related depression was higher, and its degree was more severe than that of other cancers.