液基薄层细胞检测系统联合阴道镜下活检在诊断子宫颈病变中的意义

Meaning of fluid based thin-layer cytological test system united with cervical biopsy under colposcope in diagnosing pathological changes of cervix uteri

目的研究液基薄层细胞学(LCT)联合阴道镜对宫颈病变筛查的临床应用价值。方法选择妇科门诊临床可疑患者490例进行宫颈病变筛查并分组,试验组250例行LCT联合阴道镜检查并镜下指导活检,对照组240例行直接阴道镜检查并镜下指导活检,最终均以组织学诊断为金标准,比较2组组织学诊断阳性符合率。结果试验组组织学诊断阳性符合率为74.44%,对照组为52.08%,2组诊断符合率比较有显著性差异(P<0.01)。结论采用LCT筛查可早期发现宫颈病变,细胞学阳性或临床可疑者应配合阴道镜检查及镜下活检,但如果同时进行液基薄层细胞检测可提高宫颈上皮内瘤变的检出率。

Objective It is to study the clinical application value of liquid crystal thermography （LCT） united with colposcope for screening of pathological changes of cervix uteri. Methods 490 clinical suspected patients in clinic service in department of gynecology were chosen for screening of pathological changes of cervix uteri and divided groups. 250 cases were in test group and examined with LCT united with vaginoscopy and biopsy under colposcope. The other 240 cases were in control group and immediately examined with vaginoscopy and biopsy under colposcope. Histodiagnosis was taken as gold standard in fine. The positive coincidences of histodiagnosis in the two groups were compared. Results The positive coincidences of histodiagnosis in test group was 74.44 % and that in control group was 52.08 %, and there was significant difference between the two groups （P〈 0.01）. Conclusion LCT screening can detect pathological changes of cervix uteri in early phase. The patients whose cytological test results are positive or clinical suspected should receive vaginoscopy and biopsy under colposcope, but LCT detected at the same time can heighten the detection rate of cervical intraepithelial neoplasia.