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中国汉族人群Diego血型基因频率调查研究 被引量:13

Investigation on Diego gene frequency in Chinese Han population
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摘要 目的调查研究中国汉族人群的Diego血型基因频率分布。方法用血型血清学方法对1577例非相关的献血者进行Diego血型的筛选鉴定,并对部分标本进行基因分型和基因测序。结果1577例标本Diego血型血清学鉴定结果,Dia+b-1例,Dia+b+47例,Dia-b+1529例。结论汉族人群DI1基因频率为0.0155,DI2基因频率为0.9845。 Objective To investigate the Diego gene frequency in Chinese Han population. Methods 1 577 blood samples from unrelated blood donors were phenotyped for Dia and Dib,part of DNA samples were studied by PCR-SSP and direct sequencing. Results 1529 of 1577 cases were Di(a-b-/ ),47 of them were Di(a-/ b+),one of them was Di(a+b ) ,respectively. Conclusion DI1 gene frequency is 0. 015 5,DI2 gene frequency is 0. 984 5.
作者 刘宇 牛淼
出处 《检验医学与临床》 CAS 2010年第4期308-309,311,共3页 Laboratory Medicine and Clinic
关键词 汉族 红细胞 基因频率 聚合酶链反应 血型抗原 陕西 han nationality erythroeytes gene frequency polymerase chain reaction blood group an tigens Shanxi
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  • 1Wu GG, Su YQ, Yu Q, et al. Development of a DNA- based genotyping method for the Diego blood group system[J]. Transfusion, 2002,42 : 1558-1556.
  • 2Komatsu F, Hasegawa K, Yanagisawa Y, et al. Prevalence of Diego blood group Dia antigen in Mongolians; comparison with that in Japanese[J]. Transfus Apher Sci, 2004, 30(2) :119-124.
  • 3袁义达,金锋,杜若甫,龙邕泉,蔡瑞霖.侗族九个红细胞血型系统和ABH分泌型的分布[J].人类学学报,1984,3(3):277-284. 被引量:17
  • 4Ting JY,Ma ES,Wong KY. A case of severe haemolytic disease of the newborn due to anti-Di ( a) antibody [J].Hong Kong Med J,2004,10(5):347-349.
  • 5刘孟黎,蒋冬玲,刘晟.Diego血型基因在西安地区汉族人群中的频率分布[J].西安交通大学学报(医学版),2003,24(4):348-349. 被引量:16

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