脑卒中患者骨密度变化及其影响因素

Changes of Bone Mineral Density and the Influencing Factors in Stroke Patients

目的:研究脑卒中患者骨密度(BMD)变化及影响因素。方法:采用双能X线BMD仪对32例脑卒中患者(卒中组)患侧股骨和10例健康人(对照组)股骨进行BMD及T分值检测,分析影响BMD变化的可能因素。结果:卒中组患者BMD明显低于对照组(P<0.01);回归分析显示,卒中组患者患侧股骨颈(Neck)BMD与性别呈负相关,三角区(Ward)BMD与病程呈负相关(均P<0.05);大转子(GT)BMD与性别呈正相关(P<0.01),与病程呈负相关(均P<0.01)。T分值分析中,GT有相关的影响因素为性别,即男性T分值高于女性。结论:脑卒中患者患侧股骨BMD明显下降;性别和病程与BMD改变密切相关,是主要影响因素。

Objective：To study changes of bone mineral density （BMD） and the influencing factors in stroke patients. Methods： Thirty-two cases of stroke as case group and 10 healthy controls as normal control group were studied. BMD was examined by dual-energy X-ray Absorptiometry （DXA）. BMD and T score were compared between two groups, and the possible influencing factors （age, sex, weight, height and disease duration） in the patients with stroke were analyzed. Results： The BMD in patients with stroke was decreased significantly as compared with that in the normal control group （P〈0.01）. The multivariable stepwise regression analyses revealed that BMD in the neck of femur at the affected side was negatively correlated with sex （P〈0.05）, and that in the Ward negatively correlated with disease duration （P〈0.05）. BMD in the greater trochanter （G.T） at the affected side was positively correlated with sex （P〈0.01）, but negatively correlated with disease duration （P〈0.01）. Only T score of G.T had some influencing factors and sex was the major factor. T score in the G.T was negatively correlated with sex （P〈0.01）. Conclusion： BMD in patients with stroke was decreased significantly. Sex and disease duration in stroke patients were significantly correlated with BMD.