老年周围动脉闭塞性疾病患者D-二聚体与超敏C反应蛋白的关系

Analysis of the Relationship between D-dimer and High-sensitivity C-reactive Protein in Elderly Patients with Peripheral Arterial Occlusive Disease

目的:探讨老年周围动脉闭塞性疾病(PAOD)患者血浆D-二聚体(D-D)与超敏C反应蛋白(hs-CRP)关系。方法:老年PAOD患者100例为A组,体检健康对照者40例为B组。2组均在入院24h内检测血浆hs-CRP和D-D的浓度,并进行统计学分析。结果:A组血浆hs-CRP和D-D浓度均高于B组(P<0.01);且D-D与hs-CRP呈显著正相关(P<0.01)。结论:hs-CRP是D-D升高的主要相关因素;hs-CRP和D-D的升高也许是老年PAOD的危险因素,也是PAOD诊断、治疗和预后评价的可靠实验室指标。

Objective：To study the relationship between D-dimer （D-D） and high-sensitivity C-reactive protein （hs-CRP） in elderly patients with peripheral arterial occlusive disease （PAOD）. Methods：100 elderly patients with PAOD served as group A, and 40 healthy volunteers as control group （group B）, who were admitted from July 2006 to August 2008. Plasma hs-CRP and D-D within 24 h after admission were measured, and the data were analyzed statistically. Results：The levels of plasma hs-CRP and D-D in group A were higher than in group B （P〈0.01）. There was a positive correlation between D-D and hs-CRP in group A （P〈0.01）. Conclusion：（1） hs-CRP is a major factor related to the rise of D-D. （2） The increase in the levels of hs-CRP and D-dimer may be the dangerous factors and reliable indexes of laboratory diagnosis, treatment and prognostic evaluation for elderly PAOD patients.