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1.06μm激光致皮肤痛觉效应的研究 被引量:1

1.06μm Laser Stimulus Causing Pain in Human Skin
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摘要 目的:研究1.06μm激光所致人手背皮肤的痛觉效应。方法:以输出波长为1.06μm的脉冲Nd:YAG激光照射人手背皮肤,记录每次刺激激光的能量以及受试者的反应。采用加权概率单位算法计算诱发痛觉概率为50%时对应的激光剂量ED50,即为痛觉阈值。改变光斑大小和脉冲宽度,测定三种不同刺激条件下的痛觉阈值,并探索温度对激光所致痛觉效应的影响。结果:当皮肤温度约为30℃,分别使用光斑直径1.20mm、脉冲宽度85μs,光斑直径1.20 mm、脉冲宽度20 ns和光斑直径2.56 mm、脉冲宽度20 ns的激光刺激时,痛觉阈值分别为394 mJ/mm^2、36.4 mJ/mm^2和8.92 mJ/mm^2。在第一种刺激条件下,当皮肤温度为25℃时,剂量为383 mJ/mm^2的激光诱发痛觉的概率为16.7%;当皮肤温度为39℃C时,剂量为361 mJ/mm^2的激光诱发痛觉的概率为56.7%。结论:1.06μm激光所致痛觉的阈值随脉冲宽度的减小、光斑面积的增大和皮肤表面温度的增加而减小。 Objective: To study 1.06 μm laser stimulus causing pain in human skin. Methods:The skin of human dorsum hand was irradiated by a neodymium :yttrium aluminum gamet (Nd:YAG) laser. The energy of each pulse and whether the subjects felt a painful sensation after each stimulus were recorded. The pain threshold was defined as the laser dose at which the subjects reported a painful sensation to 50 % of stimulus deliveries. The pain thresholds were determined under 3 different beam diameters and pulse duration conditions. The influence of skin temperature on the pain caused by laser stimulus was also explored. Results:As the temperature of skin was about 30 ℃, the pain thresholds were determined to be 394 mJ/mm^2 , 36, 4 mJ/mm^2 and 8.92 mJ/mm^2 respectively under the stimulating condition of 1.20 mm beam diameter and 85 μs pulse duration, 1.20 mm beam diameter and 20 ns pulse duration and 2.56 mm beam diameter and 20 ns pulse duration. Under the first condition, when skin temperature was 25 ℃ and radiant expo-sure was 383 mJ/mm^2 , the probability of laser stimulus causing pain was 16.7 % ; when skin temperature was 39 ℃ and radiant exposure was 361 mJ/mm^2, the probability was 56.7 % . Conclusion : The threshold of 1 .06 μm laser stimulus causing pain decreases with decreasing pulse duration, increasing beam diameter and increasing skin temperature.
出处 《激光生物学报》 CAS CSCD 2010年第1期5-9,共5页 Acta Laser Biology Sinica
基金 国家自然科学基金资助项目(30600493) 国家科技重大专项课题
关键词 激光 皮肤 痛觉阈值 光斑直径 脉冲宽度 温度 laser skin pain threshold beam diameter pulse duration temperature
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