高血压病痰瘀互结与炎症因子相关的机制探讨

Study on interrelation between hypertension inflammatory factors and phlegm-stasis

高血压病是引发心脑血管疾病的主要危险因素之一,近年来多数学者认为血管炎性反应和内皮受损是引发并发症的重要环节。文章通过论述血管紧张素Ⅱ(AngⅡ)、白介素6(IL-6)、C-反应蛋白(CRP)、核转录因子(NF-κB)等炎症因子与血管内皮的相关性,探讨"痰瘀互结、毒损心络"可能加剧血管壁的损伤,促进动脉硬化斑块的破裂而引发并发症,揭示炎性因子是高血压病"毒"的生物学基础。目的在于揭示建立以中医预防为主的"治未病"预警系统和"既病防变"的干预措施,为临床防治高血压病提供新的思路与方法。

Hypertension is one of the main risk factors causing cerebrovascular diseases. In eecent years, most scholars think that vascular inflammatory reaction and endothelial damage are the important reasons for complication. Through investigating the correlation between vascular endothelial and inflammatory factors Ang ]1, IL-6, CRP and NF-tcB, it obtained that the poison damaged heart meridian syndrome and phlegm-stasis may increase the damage of vascular wall, promote the rupture of atherosclerotic plaque and cause the complication. It showed that inflammatory factors were the biological basis of hypertension illness ＇poison＇. The objective was to build the ＇disease prevention first＇ warning system and the intervention of ＇prevention of progress of disease＇, and to provide the new idea and method for clinical prevention of hypertension illness.