安律胶囊对豚鼠心室肌细胞钠离子通道的影响

Effect of Anlv Capsule on sodium ion channels in ventricular myocytes of guinea pig

目的:通过观察安律胶囊对豚鼠心室肌细胞钠电流(INa)的影响,以探讨其抗早搏的作用机制。方法:采用膜片钳全细胞记录技术记录了安律胶囊对单个豚鼠心室肌细胞钠电流的影响。结果:安律胶囊可剂量依赖性的阻滞钠电流且具有一定的使用依赖性和时间依赖性。结论:安律胶囊对钠电流的阻滞作用是其抗早搏的作用机制之一。

Objective： To observe the effect of Aalv Capsule on sodium current in guinea pig ventricular myocytes （INa） for exploring the mechanism of its anti-premature beats. Methods： Whole-cell patch-clamp recording technique was used to record the Aalv Capsule for a single cell of sodium currents in guinea pig ventricular myocytes. Results： There was dose-dependent of Aalv Capsule in block of sodium currents and had a certain amount of use-dependent and time-dependent. Conclusion ： The role of Aalv Capsule in blocking sodium current block was one of the mechanisms of its in beating premature.