肺泡表面活性物质联合鼻塞持续气道正压通气治疗早产儿呼吸窘迫综合征的疗效及护理

Effect and nursing of pulmonary surfactant combined continuous positive airway pressure therapy premature infants with respiratory distress syndrome

目的:观察肺泡表面活性物质治疗早产儿呼吸窘迫综合征的疗效。方法:将156例呼吸窘迫综合征患儿随机分为治疗组(78例)及对照组(78例)。治疗组于出生后30min～2h从气管插管内滴入肺泡表面活性物质(固尔苏),每次100～200mg/kg,用药后应用鼻塞持续气道正压(NCPAP)装置辅助呼吸;对照组单纯应用NCPAP装置辅助呼吸。两组其他治疗及护理措施相同。结果:治疗组辅助呼吸、机械通气、住院时间明显缩短,与对照组比较,差异有显著性(均P<0.05);治疗组72h胸部X线摄片正常率高于对照组(P<0.05)。结论:保持呼吸道通畅,采取正确的氧疗和加强机械通气的管理,配合早期足量的应用肺泡表面活性物质,可提高呼吸窘迫综合征患儿的疗效和缩短病程。

Objective ：To observe the effect of pulmonary surfactant treatment of respiratory distress syndrome in premature infants. Methods ：156 eases of respiratory distress syndrome in premature infants were randomly divided into treatment group （78 cases） and control group （78 cases）. Treatment group was born from 30 rain to 2 h instillation with endotracheal intubation pulmonary suffactant （Curosuff） 100 -200 mg/kg. Pertime, after drug application of nasal continuous positive airway pressure （NCPAP） ventilation devices;control simple application of NCPAP group assisted breathing device; the others with the same treatment and care measures in two groups. Results：The treatment group - assisted breathing, Mechanical ventilation, length of stay was significantly shorter, compared with the control group, there were significant differences （all P 〈 0.05 ） ;72 h chest X -ray rate in treatment group was higher than in control group （P 〈 0.05 ）. Conclusion ：Maintain airway, oxygen therapy and the fight to take to strengthen the management of mechanical ventilation, with early application of adequate pulmonary surfactant, to improve prevention and treatment of complications in premature infants with respiratory distress syndrome in children with the efficacy and shorten the course.