摘要
目的探讨水通道蛋白-1(AQP-1)mRNA在甲状腺癌组织中的表达和意义。方法应用RT-PCR法检测20例甲状腺癌患者癌组织,其中15例的癌旁正常组织和15例甲状腺腺瘤的正常甲状腺组织中AQP-1mRNA的表达情况。结果甲状腺癌组织AQP-1mRNA的表达水平较癌旁正常组织、正常甲状腺组织明显增强,两者之间的差异有统计学意义(均P<0.05)。结论AQP-1mRNA在甲状腺癌组织中表达增强可能与甲状腺癌的发生、发展有一定关联。
Objective To detect expression and significance of water channel aquaporin-1 （AQP-1） mRNA in thyroid carcinoma tissues. Methods Twenty cases of thyroid carcinoma tissues in which 15 cases of normal tissues beside tumors, and 15 cases of normal tissues of thyroid adenomas were acquired immediately after surgery. The expression of AQP-1 mRNA in thyroid carcinoma were examined by RT-PCR technique. Results AQP-1 mRNA expression level in thyroid carcinoma tissues was significantly stronger than that in normal tissues beside tumors and normal thyroid tissues （P〈0.05 for each）. Conclusion The expression of AQP-1 mRNA can enhance in thyroid carcinoma tissues. It suggest that AQP-1 mRNA expression may be relate to the happening and developing of thyroid carcinoma.
出处
《福建医药杂志》
CAS
2010年第1期96-97,共2页
Fujian Medical Journal
