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糖尿病肾脏微血管病变的研究进展 被引量：7

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摘要 糖尿病肾病（DN）是糖尿病慢性微血管病变在肾脏的表现,而蛋白尿的出现则提示糖尿病肾脏广泛微血管损害。近年研究发现许多促血管生成因子在DN发生、发展中扮演重要作用。
作者 孙永胜 杨亦彬
机构地区 遵义医学院附属医院肾病风湿科
出处 《现代医药卫生》 2010年第4期544-546,共3页 Journal of Modern Medicine & Health
关键词 肾脏微血管病变 糖尿病肾病 促血管生成因子 微血管损害 糖尿病肾脏 蛋白尿
分类号 R587.2 [医药卫生—内分泌] R331.32 [医药卫生—人体生理学]
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参考文献19

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  • 2Yamamoto Y,Maeshima Y, Kitayama H,et al.Tumstatin peptide,an inhibitor of angiogenesis, prevents glomerular hypertrophy in the early stage of diabetic nephropathy[J].Diabetes, 2004,53 : 1831.
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二级参考文献18

  • 1Calles-Escandon J, Gipolla M. Diabetes and endothelial dysfunction: a clinical perspective. Endocr Rev,2001,22(1) :36 - 52.
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  • 5Yamamoto Y, Maeshirna Y, Kitayama H,et al. Tumstatin peptide, an inhibitor of angiogenesis, prevents glomerular hypertrophy in the early stage of diabetic nephropathy. Diabetes, 2004, 53(7) : 1831 - 1840.
  • 6Nyengaard JR, Rasch R. The impact of experimental diabetes mellitus in rats on glomerular capillary number and sizes. Diabetologia, 1993,36(3):189 - 194.
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  • 8Kang DH, Kanellis J, Hugo C, et al. Role of the microvascular endothelium in progressive renal disease. J Am Soc Nephrol, 2002,13(3) :806- 816.
  • 9Khamaisi M, Schrijvers B,De Vriese AS,et al. The emerging role of VEGF in diabetic kidney disease. Nephrol Dial Transplant,2003,18(8) : 1427 - 1430.
  • 10Logothetis CJ,Wu KK, Finn LD, et al. Phase Ⅰ trial of the angiogenesis inhibitor TNP- 470 for progressive and rogen- independent prostate cancer. Clinical Cancer Research,2001,7 (5) : 1198 - 1203.

共引文献5

同被引文献66

引证文献7

二级引证文献32

现代医药卫生
2010年 第4期

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