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动态动力学拆分制备手性化合物的研究进展 被引量：2

Research progress of dynamic kinetic resolution for preparation of chiral compounds
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摘要 综述了固体酸、固体碱和金属配合物在动态动力学拆分制备光学纯手性化合物进行外消旋化的催化机理,讨论了均相外消旋催化剂和多相外消旋催化剂在动态动力学拆分工艺中的应用,重点介绍了过渡金属配合物催化剂和生物酶配伍进行动态动力学拆分制备手性化合物的研究进展和发展趋势。 The racemic catalytic mechanisms of solid acid, solid base and metal complexes for the preparation of optically pure chiral compounds by dynamic kinetic resolution were summarized. The application of homogeneous racemic catalysts and heterogeneous catalysts in dynamic kinetic resolution process was also discussed. Based on this, the article focuses on the compatibility of transition metal complex catalysts and bio-enzyme catalysts for the preparation of chiral compounds by dynamic kinetic resolution in research and development trends.
作者 王雷 薛屏
机构地区 宁夏大学能源化工自治区重点实验室
出处 《应用化工》 CAS CSCD 2010年第2期258-263,共6页 Applied Chemical Industry
基金 国家自然科学基金项目(50662004)
关键词 动态动力学拆分 外消旋化催化剂 催化机理 金属配合物催化剂 脂肪酶 dynamic kinetic resolution racemization catalysts catalytic mechanism metal complex catalysts lipase
分类号 O643.32 [理学—物理化学]
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参考文献25

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同被引文献28

  • 1Michael.美国新生代[J].网球大师,2013,0(9):32-35. 被引量：6
  • 2辛艳飞,周向军,王永祥.D型氨基酸氧化酶活性对于D-硝基精氨酸手性转化的影响[J].生物化学与生物物理进展,2006,33(2):135-139. 被引量：2
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  • 7Lee J H, Han K, Kim M J,et al. Chemoenzymatic dynamic kinetic resolution of alcohols and amines[ J]. Eur J Org Chem,2010,6: 999-1015.
  • 8Raza S, Fransson L, Hult K. Enantioselectivity in Candida antarctica lipase B:a molecular dynamics study[ J]. Protein Sci, 2008,10(2) :329-338.
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  • 10Suyog Madhav Amrutkar,Linga Banoth,Uttam Chand Banerjee.One-pot synthesis of ( R )-1-(1-naphthyl)ethanol by stereoinversion using Candida parapsilosis[J].Tetrahedron Letters.2013(25)

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应用化工
2010年 第2期

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