摘要
目的通过应用美金刚治疗阿尔茨海默病,探讨血浆超氧化物歧化酶(SOD)和神经元特异性烯醇化酶(NSE)浓度变化与认知功能改善的关系。方法符合美国精神障碍诊断与统计手册第4版诊断标准的阿尔茨海默病(AD)患者67例,随机分为美金刚治疗组和常规治疗组,另外选取对照组39例,在入组前、治疗第1月、3月及6月时,测定其SOD和NSE浓度及进行简易精神状态检查量表(MMSE)评分。结果治疗6月后,美金刚治疗组血清SOD浓度和MMSE评分明显高于常规治疗组,NSE浓度明显低于常规治疗组(P<0.05);治疗6月后,美金刚治疗组血清SOD浓度和MMSE评分明显高于治疗前,NSE浓度明显低于治疗前(P<0.05)。结论应用美金刚治疗AD可以提高SOD含量,减少NSE生成,减轻氧化应激损伤,取得较好的疗效。
Objective To observe the effects of memantine on serum SOD and NSE in patients with Alzheimer＇s disease（AD）.Methods Sixty-seven elderly patients with AD were randomly divided into memantine treatment group and routine treatment group.Thirty-nine healthy subjects were chosen as normal group.The serum concentration of SOD was measured by chemical colorimetry.The serum concentration of NSE was measured by enzyme-linked immunosorbent assay（ELISA）.Results After 6 months of treatment,the level of serum SOD and the score of MMSE in memantine treatment group were higher than those in normal treatment group;the level of NSE in memantine treatment group was lower than that in normal treatment group.After 6 months of treatment,the serum level of SOD in memantine treatment group increased,and the serum level of NSE in memantine treatment group decreased;the score of MMSE in memantine treatment group was higher than that before treatment.Conclusions The therapy of memantine could reduce oxidative stress and get better efficacy in treating AD.
出处
《实用老年医学》
CAS
2010年第1期30-32,共3页
Practical Geriatrics
