摘要
白细胞介素1受体相关激酶(IRAKs)作为TIR(Toll/IL-1 receptor)信号通路的重要连接体,在调节机体的自身免疫中起着重要的枢纽作用。家族成员包括IRAK-1、IRAK-2、IRAK-M、IRAK-4,其中IRAK-1和IRAK-4对信号传递起正性调节作用,IRAK-2和IRAK-M起负性调节作用。近年来,随着分子生物学和流行病学研究的不断深入,IRAKs基因多态性与炎症、免疫性疾病、肿瘤、代谢性疾病、心脑血管疾病、骨质疏松等疾病的关系逐步得到证实。
Interleukin-1 receptor associated kinases（IRAKs）are pivotal adaptors in the TIR（Toll/IL-1 receptor）signaling pathway and play a central role in the regulation of innate immunity.IRAKs family has four members,IRAK1,IRAK2,IRAK-M and IRAK4,in which IRAK-1 and IRAK-4 act as up-regulating kinases while IRAK-2 and IRAK-M act as down-regulating kinases in signal transduction.Recently,the association between the polymorphism of IRAKs gene and inflammation,autoimmune diseases,oncology,metabolic diseases,cardiovascular and cerebrovascular diseases,osteoporosis have gradually been confirmed with the development of molecular biology and epidemiological studies.
出处
《医学综述》
2010年第4期498-501,共4页
Medical Recapitulate
基金
广西自然科学基金(桂科自0728160)
关键词
IRAK家族
基因多态性
易感性
Interleukin-1 receptor associated kinases
Gene polymorphism
Susceptibility
