摘要
c-Jun氨基末端激酶(JNK)家族是丝裂原活化蛋白激酶(MAPK)超家族成员之一,JNK在基因表达、细胞增殖、促凋亡等细胞调控方面具有重要作用。许多体外和活体的实验均证实JNK与眼科疾病、神经退行性病变、肿瘤、糖尿病等临床疾病有密切的联系。因此,JNK信号通路可作为临床上相关疾病的治疗靶向。
The c-Jun NH2-terminal kinases（JNK）are sub-group of mitogen-activated protein kinase（MAPK）superfamily.JNK play important roles in cell regulation such as gene expression,cell proliferation and programmed cell death.Several in vitro and in vivo studies have reported that JNK pathways are closely associated with several diseases such as ocular disease,neurodegeneration,tumor and diabetes.Therefore,JNK pathway components represent potential therapeutic targets for the treatment of related diseases.
出处
《医学综述》
2010年第4期507-509,共3页
Medical Recapitulate
