期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

心脏干细胞在心肌细胞再生中的研究 被引量：2

The Role of Cardiac Stem Cells in the Regeneration of Myocardial Cells
下载PDF
导出
摘要 心脏原位干细胞(CSCs)来源于心脏组织中,是一种未分化的细胞,其细胞膜上可同时表达干细胞相关抗原、c-kit、MDR1和Sca-1,基于不同CSCs自身抗原表达的不同,很多取自成体心脏组织的CSCs可以得到分离和扩增。CSCs能够分化成3种主要的心脏细胞前体,即心肌细胞,平滑肌细胞和上皮细胞,并且可重组为心肌组织,为使用干细胞疗法治疗心脏病提供了一个新的视角。 Cardiac stem cells（CSCs）are from heart tissue,they are a kind of undifferentiated cells,Stem cell-associated antigen,c-kit,MDR1,and Sca-1 express on the membrane of CSCs.Many kinds of CSCs which were taken from adult heart tissue can be isolated and amplified because they express different self-antigen.CSCs can differentiate into three kinds of major heart cell precursors：myocardial cells,smooth muscle cells and epithelial cells,they can be reorganized into myocardial tissue.This provides a new perspective to use stem cell to treat heart disease.
作者 王海龙 杜振宗
机构地区 桂林医学院附属医院心胸外科
出处 《医学综述》 2010年第4期516-518,共3页 Medical Recapitulate
关键词 心肌损伤 心肌细胞再生 心脏干细胞 Myocardial damage Myocardial cell renewal Cardiac stem cells
分类号 R654 [医药卫生—外科学]
  • 相关文献

参考文献27

  • 1马金本,林峰.骨髓间质干细胞改善缺血心肌心功能研究进展[J].医学综述,2005,11(9):787-789. 被引量：1
  • 2Quaini F, Urbanek K, Beltrami AP, et al. Chimerism of the transplanted heart[J]. N Engl J Med,2002,346( I ) :5-15.
  • 3Hierlihy AM, Seale P, Lobe CG, et al. The post-natal heart contains a myocardial stem cell population [ J ]. FEBS Lett, 2002,5 ( 3 ) : 239 -243.
  • 4Behrami AP, Urbanek K, Kajstura J, et al. Evidence that human cardiac myocytes divide after myocardial infarction [ J ]. N Engl J Med,2001,344(23) :1750-1757.
  • 5王月刚,吴平生.干细胞移植治疗冠心病的应用进展[J].心脏杂志,2007,19(1):91-95. 被引量：9
  • 6Matsuura K, Nagai T, Nishigaki N, et al. Adult cardiac sea-1-positive cells differentiate into beating cardiomyocytes [ J ]. J Biol Chem,2004,279(12) :11384-11391.
  • 7Anversa P, Nadal-Ginard B. Myocyte renewal and ventricular remodeling[ J]. Nature,2002,41 (5) :240-243.
  • 8Goumans M J, de Boer TP, Smits AM, et al. TGF-beta 1 induces efficient differentiation of human cardiomyocyte progenitor cells into functional cardiomyocytes invitro [ J ]. Stem Cell Res, 2008,5 ( 1 ) : 138-149.
  • 9Elisa M, Lueiana DA, Giacome F, et al. Isolation and expansion of adult cardiac stem cells from human and murineheart [ J ]. Circ Res,2004,95 ( 8 ) :911-921.
  • 10Frangogiannis NG, Perrard JL, Mendoza LH, et al. Stem cell factor induction is associated with mast cell accumulation after canine myocardial ischemia and reperfusion [ J ]. Circulation, 1998, 98 (7) :687-698.

二级参考文献77

  • 1Beltrami AP, Urbanek K, Kajstura J, et al. Evidence that humancardiac myocyte divide after myocardial infarction [ J ]. N Engl J Med, 2001,344(23) : 1750-1757.
  • 2Makino SJ, Fukuda K, Miyoshi S, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro [J] .J Clin Invest, 1999,103(5) :697-705.
  • 3Fukuda K. Molecular characterization of regenerated cardiomyocytes derived from adult mesenchymal stem cells [ J]. Congenit Anom Kyoto,2002,42(1) : 1-9.
  • 4Tomita S, Li RK, Weisel RD, et al. Autolo-gous transplantation of bone marrow cells improves damaged heart function [J]. Circulation, 1999,100[ 19 Suppl 11]:11247-256.
  • 5Wang JS, Shum TD, Galipeau J, et al. Marrow stromal cells for cellular cardiomyoplasty: feasibility and potential clinical advantages[ J]. J Thorac Cardiovasc Surg,2000,120(5) :999-1006.
  • 6Shake JG, Gruber PJ, Baumgartner WA, et al. Mesenchymal stem cell implantation in aswine myocardial infarct model: engraftmentand function effects[J]. Ann Thorac Surg,2002,73(6) : 1919-1925.
  • 7Olic D, Kajstura J, Chimenti S, et al. Bone marrow cells regenerate infracted myocardium[ J]. Nature,2001,410(6829) : 701-705.
  • 8Liu J, Hu Q, Wang Z, et al. Autologous stem cell transplantation for myocardial repair[ J]. Am J Physiol Heart Circ Physiol,2004,287(2) :H501-511.
  • 9Saito T, Kuang GQ, Bittira B, et al. Xenotransplant cardiac chimera: immune toleranceof adult stem cells [ J ]. Ann Thorac Surg, 2002,74(1) : 19-24.
  • 10Strauer BE, Brehm M, Zeus T, et al.Intracoronary, human autologous stem cell transplantation for myocardial regeneration following myocardial infarction [ J ]. Dtsch Med Wochenschr, 2001,126 (34-35) : 932-938.

共引文献8

同被引文献66

  • 1Doetschman TC,Eistetter H,Katz M,et al.The in vitro develop-ment of blastocyst-derived embryonic stem cell lines:formation of visceral yolk sac,blood islands and myocardium[J].Embiyol Exp Moiphol,1985,87:27-45.
  • 2Kehat I,Kenyagin-KarsentiD,Snir M,et al.Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytesl[J].J Clin Invest,2001,108(3):407-414.
  • 3Yuasa S,Itabashi Y,Koshimizu V,et al.Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells[J].Nat Biotechnol,2005,23(5):607-611.
  • 4Singla DK,McDonald DE.Factors released from embryonic stem cells inhibit apoptosis of H9c2 cells[J].Am J Physiol Heart Circ Physiol,2007,293(3):H1590-H1595.
  • 5Xie CQ,Zhang J,Xiao Y,et al.Transplantation of human undiffer-entiated embryonic stem cells into a myocardial infarction rat model[J].Stem Cells Dev,2007,16(1):25-29.
  • 6Cai J,Yi FF,Yang XC,et al.Transplantation of embryonic stem cell-derived cardiomyocytes improves cardiac function in infarcted rat hearts[J].Cytotherapy,2007,9(3):283-291.
  • 7Caspi O,Huber I,Kehat I,et al.Transplantation of human embry-onic stem cell-derived cardiomyocytes improves myocardial per-formance in infarcted rat hearts[J].J Am Coll Cardiol,2007,50(19):1884-1893.
  • 8Wakitani S,Saito T,Caplan Al.Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine[J].Muscle Nerve,1995,18(12):1417-1426.
  • 9Baksh D,Boland GM,Tuan RS.Cross-talk between Writ signaling pathways in human mesenchymal stem cells leads to functional an-tagonism during osteogenic differentiation[J].Cell Biochem,2007,101(5):1109-1124.
  • 10Kobune M,Kawano Y,Takahashi S,el al.Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-)cells[J].Exp Hematol,2008,36(9):1121-1131.

引证文献2

二级引证文献2

医学综述
2010年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部