期刊文献+

女性压力性尿失禁患者盆底组织分子学研究进展 被引量:4

Recent Progress on the Molecular Level of Pelvic Tissue in Female Stress Urinary Incontinence Patients
下载PDF
导出
摘要 压力性尿失禁是泌尿外科常见病,大多数学者认为年龄、体质量指数、妇科手术史、反复泌尿道感染为尿失禁的高危因素。目前关于压力性尿失禁的研究很多,盆底组织胶原降解增加引起盆底组织支持力减弱是压力性尿失禁的重要发病机制。对盆底组织分子水平的研究,有利于更进一步明确压力性尿失禁的病因,为寻找更好的预防和治疗方法提供了新的思路,现就目前的分子研究水平热点予以综述。 Stress urinary incontinence(SUI)is a common disease in the urinary surgery.Many researchers believe that age,body mass index,history of gynecologic surgery,and repeated urinary tract infections are the high risk factors for SUI.At present,a lot of researches on stress urinary incontinence reveal that collagen degradation in pelvic organ can weaken the supportive role of this tissue,which is the pathogenesis of SUI.Pelvic organ studies at the molecular level can be helpful to investigate the etiology of stress incontinence,and can provide a new way in the research of better prevention and treatment of SUI.This article reviewed the current hotspot on molecular level of pelvic tissue.
出处 《医学综述》 2010年第4期523-526,共4页 Medical Recapitulate
关键词 压力性尿失禁 结缔组织 分子水平 Stress urinary incontinence Connective tissue Molecular level
  • 相关文献

参考文献26

  • 1Goepel C, Hefler L, Methfessel HD, et al. Periurethral connective tissue status of postmenopausal women with genital prolapse with and without stress incontinence [ J ]. Acta Obstet Gynecol Seand, 2003,8(5) :659-664.
  • 2Chen BH, Wen Y, Li H,et al. Collagen metabolism and turnover in women with stress urinary incontinence and pelvic prolapse [ J ]. Int Urogynecol J Pelvic Floor Dyafunct,2002,13 (2) :80-87.
  • 3张群芳,宋岩峰,朱忠勇.压力性尿失禁患者阴道壁结缔组织MMP-2及其抑制物的表达[J].现代妇产科进展,2006,15(2):114-116. 被引量:12
  • 4Gabriel B,Dirk W,Katharina H,et al. Increased expression of matrix metalloproteinase 2 in uterosacral ligaments is associated with pelvic organ prolapse [ J ]. Int Urogynecol J, 2007, 17 ( 5 ) : 478-482.
  • 5Cecilia K, Wieslander A, Spyridon I,et al. Regulation of elastolytic proteases in the mouse vagina during pregnancy, parturition, and puerperium [ J ]. Biolog Reproduct ,2008,78 ( 3 ) :521-528.
  • 6周华,王漫丽,王鲁文.女性压力性尿失禁患者盆底组织MMP-3和Collagen Ⅲ的研究[J].中国现代医生,2008,46(10):1-3. 被引量:4
  • 7Chen B, Wen Y,Zhang Z,et al. Microarray analysis of differentially expressed genes in vaginal tissues from women with stress urinary incontinence compared with asymptomatic women [ J ]. Hum Reprod,2006,21 ( 1 ) :22-29.
  • 8Chen B,WenY,YuX,et al. The role of neutrophil elestase in elastin metabolism of pelvic tissues from women with stress urinary incontinence[ J]. Neurourol Urodyn ,2007,26(2) :274-279.
  • 9Douglas T, Heinemann S, Bierbaum S, et al. FibriUogenesis of collagen types Ⅰ, Ⅱ , and Ⅲ with small leucine-rich proteoglycans decofin and biglycan [ J ]. Biomacromolecules, 2006, 7 ( 8 ) : 2388-2393.
  • 10Hosaka Y, Kirisawa R, Mafune N, et al. Downregulation of decorin and transforming growth factor-beta 1 by decorin gene suppression in tendinocytes[J]. Connect Tissue Res,2005,46( 1 ) :18-26.

二级参考文献51

  • 1陈娟,郎景和,朱兰,刘珠凤,孙大为,冷金花,任海涛,赵艳环,关宏志.压力性尿失禁及盆底组织膨出患者肛提肌形态学的观察[J].中华妇产科杂志,2004,39(8):519-521. 被引量:38
  • 2金玲,王建六.女性盆底结构功能障碍性疾病基础研究现状[J].实用妇产科杂志,2005,21(3):130-132. 被引量:37
  • 3张群芳,宋岩峰,朱忠勇.压力性尿失禁患者阴道壁结缔组织MMP-2及其抑制物的表达[J].现代妇产科进展,2006,15(2):114-116. 被引量:12
  • 4Brown JS,Grady D,Ouslander JC,et al.Prevalence of urinary incontinence and associated risk factors in postmenopausal women:Heart and estrogen/progestin replacement study(HERS) Research Group[J].Obstet Gynecol,1999,94:66-70
  • 5Mohammed S.R,Suman K,Stephen F,et al.Expression profiles of collagens,Hsp47.TGF-1,MMPs and TIMPs in epidermolysis bullosa acquisita[J].Cytokine,2003,207-213
  • 6Brew K,Dinakarpendian D,Nagase H.Tissue inhibitors metalloproteinases:evolution,structure and function[J].Biochem Biophys Acta,2000,1477(1-2)
  • 7Chen B,Wen Y,Yu X,et al.Elastin metabolism in pelvic tissue:is it modulated by reproductive hormones[J]?Am J Obstet Gynecol,2005,192(5):1605-1613
  • 8Chen B,Wen Y,Zhang Z,et al.Menstrual phase-dependent gene expression differences in periurethral vaginal tissue from women with stress incontinence[J].Am J Obstet Gynecol,2003,189(1):89-97
  • 9Miyamoto Y,Yoshida M,Takahashi W,et al.The effect of nitric oxide on acetylcholine release in the rabbit bladder[J].Eur J Pharmacol,2001,428(1):59-67.
  • 10Ziessen T,Moncada S,Cellek S.Characterization of the non-nitrergic NANC relaxation responses in the rabbit vaginal wall[J].Br J Pharmacol,2002,135(2):546-554.

共引文献35

同被引文献33

引证文献4

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部