期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Noxa的促凋亡作用与肿瘤关系的研究进展 被引量：3

Progress on Pro-Apoptotic Effect of Noxa on Tumor
下载PDF
导出
摘要 Noxa是Bcl-2家族中促凋亡的BH3-only亚家族成员之一,是p53的下游靶基因,其表达主要受p53调控。它定位于线粒体,其BH-3结构域主要与Mcl-1结合,启动caspase级联反应,诱导细胞凋亡。Noxa可以通过p53依赖途径及p53非依赖途径促进细胞凋亡,在肿瘤的形成和治疗中发挥着重要作用。 Noxa is a member of pro-apoptotic BH3-only subfamily in Bcl-2 family,it is a p53 downstream target gene,whose expression was mainly regulated by p53.It is located in mitochondria,the BH-3 domain on Noxa is mainly bind with Mcl-1,thus start the caspase cascade and induce cell apoptosis.Noxa promote apoptosis via p53-dependent and p53-independent mechanisms,it plays a prominent role in the formation and treatment of tumors.
作者 马薇 王玉明 段勇
机构地区 昆明医学院第一附属医院检验科
出处 《医学综述》 2010年第4期561-563,共3页 Medical Recapitulate
关键词 NOXA P53 凋亡 肿瘤 Noxa p53 Apoptosis Tumor
分类号 R543 [医药卫生—心血管疾病]
  • 相关文献

参考文献27

  • 1Oda E,Ohki R, Murasawa H,et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis [ J]. Science,2000,288 (5468) : 1053-1058.
  • 2陈韵如,王玉明,段勇.PUMA的促凋亡作用与肿瘤治疗[J].医学综述,2008,14(24):3713-3716. 被引量：2
  • 3Ishida M,Sunamura M, Furukawa T, et al. The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer [ J ]. Dig Dis Sei,2008,53 (9) :2576-2582.
  • 4Villunger A, Michalak EM, Couhas L, et al. p53-and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa [ J ]. Science ,2003,302 (5647) : 1036-1038.
  • 5Wang Z, Sun Y. Identification and characterization of two splicing variants of human noxa [ J ]. Anticancer Res, 2008,28 ( 3A ) : 1667 -1674.
  • 6Kim JY, Ahn HJ, Ryu JH, et al. BH3-only protein noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1 alpha[ J ]. J Exp Med,2004,199 ( 1 ) : 113-124.
  • 7Sun Y,Learnan DW. Involvement of Noxa in cellular apoptotie responses to interferon, double-stranded RNA and virus infection [J]. J Biol Chem,2005,280(16) :15561-15568.
  • 8Hershko T, Ginsberg D. Up-regulation of Bcl-2 homology ( BH3 ) - only proteins by E2F1 mediates apoptosis [ J ]. J Biol Chem, 2004, 279(10) :8627-8634.
  • 9Fribley AM, Evenchik B, Zeng Q, et al. Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa[ J]. J Biol Chem,2006,281 (42) : 31440-31447.
  • 10Naik E,Michalak EM,Villunger A,et al. Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa [ J ]. J Cell Biol,2007,176 (4) :415-424.

二级参考文献79

  • 1吴志鹏,滕安宝,黄强,吴立胜.三氧化二砷诱导人胆管癌细胞系QBC939凋亡的实验研究[J].安徽医科大学学报,2004,39(5):339-342. 被引量：3
  • 2张克君,李德春,朱新国,朱东明,赵志泓.PUMA基因转染对胰腺癌细胞生长的影响[J].胰腺病学,2006,6(6):355-357. 被引量：3
  • 3王新颖,何美蓉,李明,姜泊.PUMA在奥沙利铂治疗大肠癌中作用机制的实验研究[J].医学研究生学报,2007,20(4):366-369. 被引量：8
  • 4Yu J,Zhang L, Hwang PM. PUMA induces the rapid apoptosis of colorectal cancer cells[ J]. Mol Cell ,2001,7 (3) :673-682.
  • 5Nakano K,Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53 [ J]. Mol Cell ,2001,7 ( 3 ) :683-694.
  • 6Han JW, Flemington C, Houghton AB, et al. Expression of bbc, a pro-apoptotic BH3-only gene,is regulated by diverse cell death and survival signals[J]. PNAS,2001,98(20) :11318-11323.
  • 7Yu J, wang Z, Kinzler KW, et al. PUMA mediates the apoptotic response to p53 in colorectal cancer cells [ J ]. PNAS,2003,100 (4) : 1931-1936.
  • 8Tong Y, Yang Q, Vater C, et al. The pro-apoptotic protein, Bik, exhibits potent antitumor activity that is dependent on its BH3 domain[J], nol Cancer Ther,2001,1 (2) :95-102.
  • 9Ashkenazi A,Dixit VM. Death receptors:signaling and modulation[J]. Science, 1998,281 (5381) : 1305-1308.
  • 10Geren DR, ReedJ C. Mitochondria and apoptosis [ J ]. Science, 1998,281 (5381) :1309-1312.

共引文献20

同被引文献16

  • 1陈厚早,张祝琴,韦玉生,刘德培.去乙酰化酶SIRT1的研究进展[J].中国医学科学院学报,2007,29(3):441-447. 被引量：16
  • 2Jemal A, Siegel R, Ward E, et al. Cancer statistics: 2009[J]. CA Cancer J Clin,2009,59(4):225-249.
  • 3Wang Z, Sun Y. Identification and characterization of two splicing variants of human Noxa[J]. Anticancer Res, 2008,28 (3A) :1667-1674.
  • 4Meng Y, Tang W, Dai Y, et al. Natural BH3 mimetic (-)- gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa[J]. Mol Cancer Ther,2008,7(7) :2192-2202.
  • 5Okumura K, Huang S, Sinicrope F A. Induction of Noxa sensitizes human coloreetal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737 [ J ]. Clin Cancer Res,2008,14(24) :8132-8142.
  • 6Suzuki S, Nakasato M, Shibue T, et al. Therapeutic potential of proapoptotic molecule Noxa in the selective elimination of tumor cells[J]. Cancer Sci,2009,100(4) : 759-769.
  • 7Yan J, Xiang J, Lin Y, et al. Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation[J]. Cell,2013,152(1/2) :304-315.
  • 8Zu G,Ji A,Zhou T,Che N.Clinicopathological significance of SIRT1 expression in colorectal cancer:a systematic review and meta analysis[J].Int J Surg,2016,26:32-7.
  • 9Duan K,Ge Y C,Zhang X P,et al.miR-34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression[J].Oncol Lett,2015,10(5):3223-7.
  • 10Cao Y W,Li Y C,Wan G X,et al.Clinicopathological and prognostic role of SIRT1 in breast cancer patients:a meta-analysis[J].Int J Clin Exp Med,2015,8(1):616-24.

引证文献3

二级引证文献17

医学综述
2010年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部