降糖药二甲双胍抗肿瘤的作用机制

The Antitumor Mechanism of Metformin

抗糖尿病药物盐酸二甲双胍具有抗前列腺癌、乳腺癌、胰腺癌、结直肠癌等肿瘤细胞的作用,通过抑制肿瘤细胞的增殖,为肿瘤术后复发的控制开辟了一条新的路径。现从细胞周期和分子机制方面就降糖药二甲双胍对肿瘤的抑制作用予以综述。

Metformin hydrochloride,an antidiabetic drug,have a good antitumoral effect on prostate cancer,breast cancer,pancreatic cancer,colorectal cancer and other tumor cells,It provide a new way to control tumor recurrence by inhibiting tumor cell proliferation.This article summarizes the antitumor effect of metformin in terms of cell cycle and molecular mechanisms.