冰醋酸高渗盐水混合物作为肝脏射频消融增效剂的病理及CT改变的实验研究

An experimental study of CT and pathologic features and evaluating feasibility at Hepatic radio frequency enhanced with hypertonic saline and acetic acid′s mixture

目的评价冰醋酸高渗盐水(AAHS)作为射频消融增效剂的可行性。方法将21只大耳白兔分为急性期和观察期两组,观察其CT及病理学表现。结果大体病理表现:急性期表现为浅黄色凝固坏死周围绕以充血带;观察期为白色纤维薄膜所包绕。术后1周凝固性坏死区周围有大量炎性细胞浸润,并可见消融区血管内血栓形成;术后3周坏死区为纤维囊包绕。CT表现:术后1周消融灶周边明显强化,术后3周消融灶明显减小。观察组6例发生与手术相关的并发症。结论50%AAHS溶液作为射频消融增效剂虽然可产生相应的并发症,但随着时间的推移,并发症可缓解或消失,因此是安全、可行的。

Objective To evaluate the feasibility of AAHS-enhanced rabbits hepatic radiofrequency in vivo through CT and path- ologic features. Methods Twenty-one rabbits were assigned to two groups ： Group a ：i. e only perform RFA （n= 5） ,Group b（n= 16）. Observed the CT and pathologic features of the two groups. Results In actue group,there was a hyperremia zone surrounding the coagulative necrosis area, which correlated with formed fabric envelope three weeks later. In follow-up rabbits, there was an en- hanced rim peripheral coagulation in contrast CT scan one week after procedure. The coagulation necrosis area diminuted after three weeks. Procedure-related complications occurred in six of twelve. Conclusion Although combined 50% AAHS injection and RFA have some complications, the complications can relieve or disappear, so this procedure is safe and feasible.