C-12多肿瘤标志物蛋白芯片监测胃肠道肿瘤复发转移的临床评价

Clinical significance of C-12 multiple tumor marker protein chip in monitoring of gastrointestinal cancer and the establishing of the discriminated function for the recurrence and metastasis

目的研究C-12多肿瘤标记物蛋白芯片检测系统对胃肠道肿瘤监测的临床价值。方法将近年来检测了4次以上肿瘤标记物的29例胃肠道肿瘤患者按临床疗效与病情分为6个等级,采用统计学方法检验各肿瘤标志物表达水平与临床疗效与病情分级的关系,并建立疾病复发转移的判别方程。结果胃肠道肿瘤的临床疗效与病情分级与糖链抗原19-9(CA19-9)、癌胚抗原(CEA)、癌抗原242(CA242)、甲胎蛋白(AFP)以及癌抗原125(CA125)有关,相关系数分别为0.67、0.65、0.67、0.49、0.49。根据所建判别方程,男、女性胃肠道肿瘤患者诊断正确率分别为85.1%、91.9%。结论肿瘤蛋白芯片的检测对于胃肠道肿瘤的监测具有重要临床价值。判别方程可用于胃肠道肿瘤患者复发转移的判定。

Objective To evaluate the monitoring values of C12 multiple tumor marker protein chip for gastrointestinal cancer and to establish the discriminated function for the recurrence and metastasis. Methods Twenty-nine patients, who had been detected at least 4 times on tumor markers,were selected. Based on the treatment effect and disease condition,patients were classified for six grades. The correlation of serum level of each tumor marker with the treatment effect and disease condition and the discriminated function were analyzed by the statistics. Results The treatment effect and disease condition of gastrointestinal cancer were correla- ted with CA19-9,CEA,CA242,AFP and CA125. The correlation coefficient was 0. 67,0.65,0.67,0.49,0.49,respectively. Based on the discriminated function, the percent of ＂grouped＂ male and female cases correctly classified was 85. 1%and 91.9%respectively. Conclusion There is important clinical significance of C-12 multiple tumor marker protein chip in monitoring of gastrointes tinal cancer. The discriminated function can apply to gastrointestinal cancer for discriminating recurrence and metastasis.